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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Molecular biology and evolution
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41964527/ |
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| _version_ | 1868266061984432128 |
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| author | Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian |
| author_facet | Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian |
| collection | PubMed - marine biology |
| contents | Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens. Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian Animals Body Patterning Wnt Signaling Pathway Placozoa Biological Evolution Body axis formation was a pivotal innovation in animal evolution, providing the spatial framework necessary for organized multicellularity. While the genetic basis of axis specification is well established in bilaterians, how axial organization emerged in early-diverging metazoans remains unresolved. Here, we address this question in Trichoplax adhaerens, a placozoan representing one of the simplest extant animal body plans. We show that Wnt signaling, a conserved regulator of axial patterning, exhibits polarized expression enriched in the peripheral region of this morphologically simple organism. Functional perturbations demonstrate that Wnt activity promotes peripheral cell proliferation and maintains central-peripheral tissue balance. Transcriptomic profiling further reveals distinct molecular identities along this axis, resembling the oral-aboral polarity of cnidarians. Together, our findings uncover a Wnt-dependent axial system in placozoans and support the view that core components of metazoan body axis patterning were already established in early animal evolution. |
| format | Artículo científico |
| id | pubmed_41964527 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Molecular biology and evolution |
| record_format | pubmed |
| spellingShingle | Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens. Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian Animals Body Patterning Wnt Signaling Pathway Placozoa Biological Evolution Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens. Di, Guotao Jin, Minjun Li, Wanqing Yuan, Meng Zhang, Yifan Zhao, Chengtian Animals Body Patterning Wnt Signaling Pathway Placozoa Biological Evolution Body axis formation was a pivotal innovation in animal evolution, providing the spatial framework necessary for organized multicellularity. While the genetic basis of axis specification is well established in bilaterians, how axial organization emerged in early-diverging metazoans remains unresolved. Here, we address this question in Trichoplax adhaerens, a placozoan representing one of the simplest extant animal body plans. We show that Wnt signaling, a conserved regulator of axial patterning, exhibits polarized expression enriched in the peripheral region of this morphologically simple organism. Functional perturbations demonstrate that Wnt activity promotes peripheral cell proliferation and maintains central-peripheral tissue balance. Transcriptomic profiling further reveals distinct molecular identities along this axis, resembling the oral-aboral polarity of cnidarians. Together, our findings uncover a Wnt-dependent axial system in placozoans and support the view that core components of metazoan body axis patterning were already established in early animal evolution. |
| title | Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens. |
| topic | Animals Body Patterning Wnt Signaling Pathway Placozoa Biological Evolution |
| url | https://pubmed.ncbi.nlm.nih.gov/41964527/ |