A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance.
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Journal of agricultural and food chemistry
2026
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| _version_ | 1868266061963460610 |
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| author | Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming |
| author_facet | Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming |
| collection | PubMed - marine biology |
| contents | A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance. Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming Animals Mice Allergens Immune Tolerance Epitopes, T-Lymphocyte Crassostrea Peptides Arginine Kinase Mice, Inbred BALB C Humans Tropomyosin Female Shellfish Hypersensitivity T-Lymphocytes, Regulatory Interleukin-10 The major allergens identified in include tropomyosin (Cra a 1) and arginine kinase (Cra a 2). Currently, there are few studies on oral desensitization agents designed to concurrently target two oyster allergen components. In this study, a tandem peptide (Cra a T), containing T-cell epitopes of Cra a 1 and Cra a 2, was prepared based on bioinformatics and genetic engineering technology. By incubating with splenocytes from Cra a 1/Cra a 2-sensitized mouse and establishing a DC-T coculture system, it was found that Cra a T could consistently stimulate the proliferation of CD4T cells, promote Treg cell differentiation, and upregulate the secretion of interleukin-10. Moreover, serological assays confirmed that Cra a T exhibited markedly reduced immunobinding activity against both Cra a 1 and Cra a 2. Overall, hypoallergenic Cra a T has the potential to induce dual immune tolerance and is a candidate for oyster oral desensitization preparations. |
| format | Artículo científico |
| id | pubmed_41985099 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Journal of agricultural and food chemistry |
| record_format | pubmed |
| spellingShingle | A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance. Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming Animals Mice Allergens Immune Tolerance Epitopes, T-Lymphocyte Crassostrea Peptides Arginine Kinase Mice, Inbred BALB C Humans Tropomyosin Female Shellfish Hypersensitivity T-Lymphocytes, Regulatory Interleukin-10 A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance. Gu, Yi Huan, Fei Gao, Shuai Liu, Meng Ni, Ling-Na Wu, Ming-Xuan Huang, Xin-Yi Yang, Yang Lai, Dong Liu, Guang-Ming Animals Mice Allergens Immune Tolerance Epitopes, T-Lymphocyte Crassostrea Peptides Arginine Kinase Mice, Inbred BALB C Humans Tropomyosin Female Shellfish Hypersensitivity T-Lymphocytes, Regulatory Interleukin-10 The major allergens identified in include tropomyosin (Cra a 1) and arginine kinase (Cra a 2). Currently, there are few studies on oral desensitization agents designed to concurrently target two oyster allergen components. In this study, a tandem peptide (Cra a T), containing T-cell epitopes of Cra a 1 and Cra a 2, was prepared based on bioinformatics and genetic engineering technology. By incubating with splenocytes from Cra a 1/Cra a 2-sensitized mouse and establishing a DC-T coculture system, it was found that Cra a T could consistently stimulate the proliferation of CD4T cells, promote Treg cell differentiation, and upregulate the secretion of interleukin-10. Moreover, serological assays confirmed that Cra a T exhibited markedly reduced immunobinding activity against both Cra a 1 and Cra a 2. Overall, hypoallergenic Cra a T has the potential to induce dual immune tolerance and is a candidate for oyster oral desensitization preparations. |
| title | A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of Shows Potential for Inducing Dual Immune Tolerance. |
| topic | Animals Mice Allergens Immune Tolerance Epitopes, T-Lymphocyte Crassostrea Peptides Arginine Kinase Mice, Inbred BALB C Humans Tropomyosin Female Shellfish Hypersensitivity T-Lymphocytes, Regulatory Interleukin-10 |
| url | https://pubmed.ncbi.nlm.nih.gov/41985099/ |