Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
ACS applied materials & interfaces
2026
|
| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42003109/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266059498258432 |
|---|---|
| author | Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing |
| author_facet | Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing |
| collection | PubMed - marine biology |
| contents | Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy. Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing Alopecia RNA, Small Interfering Animals Nanoparticles Mice Spermine Humans Receptors, Androgen Lipids Male Hair Follicle Androgenetic alopecia (AGA) is characterized by progressive hair loss caused by abnormal androgen levels in hair follicles, which has a substantial impact on both the physiological and psychological well-being of patients. The androgen receptor (AR) has been validated as an important target, and the local application of AR-targeting small-interference RNAs (siRNA) has been identified as a promising treatment for AGA. Nevertheless, the clinical utilization of RNAi therapy has been hampered by inefficient delivery, potential inflammatory responses, and poor in vivo retention capacity. Here, a series of spermine-derived ionizable lipids with varying alkyl chains (Sper-, = 8, 12, 16) were synthesized and subsequently coformulated with DSPC and a PEG-lipid to generate Sper-/siRNA lipid nanoparticles. In vitro studies have demonstrated that Sper-12-based nanoparticles facilitate efficient siRNA delivery for AR gene silencing as well as the internalization of ASOs and plasmid DNA. Further in vivo studies with intradermal administration of Sper-12/siAR nanoparticles have confirmed effective suppression of aberrant AR protein in androgenetic alopecia model mice, promotion of hair follicle proliferation, and alleviation of hair loss symptoms. The Sper-12/siRNA nanoparticles provide a versatile delivery platform to advance siRNA-based therapeutics for androgenetic alopecia. |
| format | Artículo científico |
| id | pubmed_42003109 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | ACS applied materials & interfaces |
| record_format | pubmed |
| spellingShingle | Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy. Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing Alopecia RNA, Small Interfering Animals Nanoparticles Mice Spermine Humans Receptors, Androgen Lipids Male Hair Follicle Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy. Feng, Di Hu, Yuqiang Zhang, Zhen Fan, Xinli Man, Yizhi Wang, Zi Guo, Dongyang Song, Yanmin Zhou, Jingjing Zhang, Jin Wang, Jing Wang, Qian Tang, Xinjing Alopecia RNA, Small Interfering Animals Nanoparticles Mice Spermine Humans Receptors, Androgen Lipids Male Hair Follicle Androgenetic alopecia (AGA) is characterized by progressive hair loss caused by abnormal androgen levels in hair follicles, which has a substantial impact on both the physiological and psychological well-being of patients. The androgen receptor (AR) has been validated as an important target, and the local application of AR-targeting small-interference RNAs (siRNA) has been identified as a promising treatment for AGA. Nevertheless, the clinical utilization of RNAi therapy has been hampered by inefficient delivery, potential inflammatory responses, and poor in vivo retention capacity. Here, a series of spermine-derived ionizable lipids with varying alkyl chains (Sper-, = 8, 12, 16) were synthesized and subsequently coformulated with DSPC and a PEG-lipid to generate Sper-/siRNA lipid nanoparticles. In vitro studies have demonstrated that Sper-12-based nanoparticles facilitate efficient siRNA delivery for AR gene silencing as well as the internalization of ASOs and plasmid DNA. Further in vivo studies with intradermal administration of Sper-12/siAR nanoparticles have confirmed effective suppression of aberrant AR protein in androgenetic alopecia model mice, promotion of hair follicle proliferation, and alleviation of hair loss symptoms. The Sper-12/siRNA nanoparticles provide a versatile delivery platform to advance siRNA-based therapeutics for androgenetic alopecia. |
| title | Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy. |
| topic | Alopecia RNA, Small Interfering Animals Nanoparticles Mice Spermine Humans Receptors, Androgen Lipids Male Hair Follicle |
| url | https://pubmed.ncbi.nlm.nih.gov/42003109/ |