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| Format: | Artículo científico |
| Sprache: | en |
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Metabolic brain disease
2026
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/42008032/ |
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| _version_ | 1868266059490918402 |
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| author | Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam |
| author_facet | Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam |
| collection | PubMed - marine biology |
| contents | Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced injuries in animal model. Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam Various therapeutic approaches to reduce ischemic brain injuries have been somewhat ineffective. Thymoquinone (TQ), a bioactive compound in Nigella sativa, exhibits anti-inflammatory and antioxidant properties. Transcranial photobiomodulation (tPBM), also known as low-level laser therapy (LLLT), has neuroprotective effects by modulating inflammatory and apoptotic pathways. This study investigated whether the administration of TQ as a candidate for combination therapy with tPBM could reduce ischemic brain injuries. Eighty-five Wistar male rats were randomly assigned to five groups: sham, MCAO, TQ, tPBM, and TQ + tPBM. The MCAO group was subjected to middle cerebral artery occlusion (MCAO) surgery. The sham group underwent surgery without filament insertion. The TQ group received 15 mg/kg of intraperitoneal TQ immediately after filament removal. The tPBM group was treated using a Photino brain laser probe (810 nm, 8 mW, and 30.6 J/cm²), which was applied to the cerebral surface of the rats in three sessions, each lasting 2 min. At 24 h After reperfusion, neurological deficit scores (NDS), infarct volume (IV), and brain edema in cortex, piriform cortex-amygdala, as well as the striatum of the rat brain were assessed. Histopathological parameters and brain-derived neurotrophic factor (BDNF) gene expression were also evaluated. The TQ + tPBM group significantly reduced NDS, IV, and brain edema compared to the MCAO group. Increased BDNF gene expression and decreased pyknotic cells were also observed in the TQ + tPBM group. The post-treatment administration of TQ combined with tPBM (in the short term) indicated an enhanced combined effect in reducing ischemic brain damage, potentially through BDNF upregulation. |
| format | Artículo científico |
| id | pubmed_42008032 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Metabolic brain disease |
| record_format | pubmed |
| spellingShingle | Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced injuries in animal model. Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced injuries in animal model. Jaz, Zohre Fendereski Bigdeli, Mohammadreza Khaksar, Sepideh Noorbakhsh, S Maryam Various therapeutic approaches to reduce ischemic brain injuries have been somewhat ineffective. Thymoquinone (TQ), a bioactive compound in Nigella sativa, exhibits anti-inflammatory and antioxidant properties. Transcranial photobiomodulation (tPBM), also known as low-level laser therapy (LLLT), has neuroprotective effects by modulating inflammatory and apoptotic pathways. This study investigated whether the administration of TQ as a candidate for combination therapy with tPBM could reduce ischemic brain injuries. Eighty-five Wistar male rats were randomly assigned to five groups: sham, MCAO, TQ, tPBM, and TQ + tPBM. The MCAO group was subjected to middle cerebral artery occlusion (MCAO) surgery. The sham group underwent surgery without filament insertion. The TQ group received 15 mg/kg of intraperitoneal TQ immediately after filament removal. The tPBM group was treated using a Photino brain laser probe (810 nm, 8 mW, and 30.6 J/cm²), which was applied to the cerebral surface of the rats in three sessions, each lasting 2 min. At 24 h After reperfusion, neurological deficit scores (NDS), infarct volume (IV), and brain edema in cortex, piriform cortex-amygdala, as well as the striatum of the rat brain were assessed. Histopathological parameters and brain-derived neurotrophic factor (BDNF) gene expression were also evaluated. The TQ + tPBM group significantly reduced NDS, IV, and brain edema compared to the MCAO group. Increased BDNF gene expression and decreased pyknotic cells were also observed in the TQ + tPBM group. The post-treatment administration of TQ combined with tPBM (in the short term) indicated an enhanced combined effect in reducing ischemic brain damage, potentially through BDNF upregulation. |
| title | Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced injuries in animal model. |
| url | https://pubmed.ncbi.nlm.nih.gov/42008032/ |