Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge .
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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Organic letters
2026
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| _version_ | 1868266059458412544 |
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| author | Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A |
| author_facet | Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A |
| collection | PubMed - marine biology |
| contents | Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge . Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A Porifera Alkaloids Animals Imidazoles Molecular Structure Vosamidines A-C (-), three polycyclic 2-aminoimidazole alkaloids, were isolated from a marine calcareous sponge, . Their structures were determined by extensive analysis of spectroscopic and spectrometric data, along with ECD computational studies. Vosamidine A possesses a 6/5/5/5/6/15(6)(5)-fused ring system based on a unique pentacyclic core. Vosamidine B is an oxidized and ring rearranged derivative of . Vosamidine C possesses an unusual 5/5/6/5/5/8 hexacyclic ring system incorporating a thioether ring. Plausible biosynthetic pathways for - are proposed. Compounds and had modest inhibition in the oncogenic fusion protein kinase DNAJB1-PKAcα assay. |
| format | Artículo científico |
| id | pubmed_42018284 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Organic letters |
| record_format | pubmed |
| spellingShingle | Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge . Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A Porifera Alkaloids Animals Imidazoles Molecular Structure Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge . Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A Porifera Alkaloids Animals Imidazoles Molecular Structure Vosamidines A-C (-), three polycyclic 2-aminoimidazole alkaloids, were isolated from a marine calcareous sponge, . Their structures were determined by extensive analysis of spectroscopic and spectrometric data, along with ECD computational studies. Vosamidine A possesses a 6/5/5/5/6/15(6)(5)-fused ring system based on a unique pentacyclic core. Vosamidine B is an oxidized and ring rearranged derivative of . Vosamidine C possesses an unusual 5/5/6/5/5/8 hexacyclic ring system incorporating a thioether ring. Plausible biosynthetic pathways for - are proposed. Compounds and had modest inhibition in the oncogenic fusion protein kinase DNAJB1-PKAcα assay. |
| title | Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge . |
| topic | Porifera Alkaloids Animals Imidazoles Molecular Structure |
| url | https://pubmed.ncbi.nlm.nih.gov/42018284/ |