Salvato in:
| Autori principali: | , , , , , , , , |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Organic letters
2026
|
| Soggetti: | |
| Accesso online: | https://pubmed.ncbi.nlm.nih.gov/42018284/ |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
Sommario:
- Vosamidines A-C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge . Senadeera, Sarath P D Wang, Dongdong Wilson, Brice A P Smith, Emily A Leal, Camille V Zhang, Ping O'Keefe, Barry R Carroll, Anthony R Beutler, John A Porifera Alkaloids Animals Imidazoles Molecular Structure Vosamidines A-C (-), three polycyclic 2-aminoimidazole alkaloids, were isolated from a marine calcareous sponge, . Their structures were determined by extensive analysis of spectroscopic and spectrometric data, along with ECD computational studies. Vosamidine A possesses a 6/5/5/5/6/15(6)(5)-fused ring system based on a unique pentacyclic core. Vosamidine B is an oxidized and ring rearranged derivative of . Vosamidine C possesses an unusual 5/5/6/5/5/8 hexacyclic ring system incorporating a thioether ring. Plausible biosynthetic pathways for - are proposed. Compounds and had modest inhibition in the oncogenic fusion protein kinase DNAJB1-PKAcα assay.