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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of natural products
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42018515/ |
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Table of Contents:
- PPTase-Based Activation Unlocks New Anthraquinones from Marine-Derived sp. SCSIO 07396. Li, Xiaohua Xia, Wanwan Liu, Changyu Sun, Changli Fang, Runping Li, Peihai Tian, Xinpeng Ma, Junying Ju, Jianhua Anthraquinones Humans Zebrafish Animals Micromonospora Molecular Structure Cell Line, Tumor Drug Screening Assays, Antitumor Transferases (Other Substituted Phosphate Groups) Antineoplastic Agents Eight new anthraquinone analogues, namely rishirilide E (), galvaquinones D-F (-), and two pairs of enantiomers, galvaquinones G (/) and H (/), together with four known compounds, rishirilide B (), galvaquinone A (), lupinacidin A (), and lupinacidin B (), were obtained from marine-derived sp. SCSIO 07396 by overexpressing the phosphopantetheinyl transferase (PPTase). Based on comprehensive HRESIMS data, NMR spectroscopic analyses, X-ray diffraction, and ECD calculations, their structures and absolute configurations were unambiguously elucidated. Assays for pro-angiogenic and anti-inflammatory effects in zebrafish models combined with cytotoxicity screening against six human cancer cell lines (PANC-1, TE-1, HL60, A549, MDA-MB-231, and GSC0722), showed that and promoted angiogenesis at 20 μM, had moderate anti-inflammatory activity at 20 μM, and exhibited cytotoxic activity against GSC0722 cells, with an IC value of 26.4 μM.