Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus.
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Aging cell
2026
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| author | Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro |
| author_facet | Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro |
| collection | PubMed - marine biology |
| contents | Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus. Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro Animals Aging Sharks Male Myocardium Female Oxidative Stress Heart Lipofuscin Myocytes, Cardiac The Greenland shark (Somniosus microcephalus), with a lifespan estimated around 300 years, represents a unique model for studying vertebrate longevity. Here, we characterize its cardiac aging profile and compare it with two other species: the deep-sea shark Etmopterus spinax and the short-lived teleost Nothobranchius furzeri. Histological analysis revealed extensive interstitial and perivascular fibrosis throughout the ventricular myocardium of S. microcephalus, affecting both compact and spongy layers of both sexes. This fibrotic pattern was absent in E. spinax and N. furzeri, suggesting it is a specific feature of S. microcephalus. We also observed extreme lipofuscin accumulation within cardiomyocytes of S. microcephalus, which correlates at the ultrastructural level with the abundance of damaged mitochondria and the presence of strikingly enlarged lysosomes filled with electrondense material of likely mitochondrial origin. Additionally, in the myocardium of S. microcephalus we found abundant deposition of the oxidative stress marker 3-nitrotyrosine. Remarkably, despite showing multiple canonical markers of aging such as fibrosis, lipofuscin accumulation, and oxidative stress, S. microcephalus individuals appeared healthy and physiologically uncompromised at the time of capture. These findings suggest that S. microcephalus has evolved resilience to molecular and tissue-level aging signs and hallmarks, supporting sustained cardiac function over centuries and offering new insights into the mechanisms of extreme vertebrate longevity. |
| format | Artículo científico |
| id | pubmed_42024652 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Aging cell |
| record_format | pubmed |
| spellingShingle | Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus. Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro Animals Aging Sharks Male Myocardium Female Oxidative Stress Heart Lipofuscin Myocytes, Cardiac Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus. Chiavacci, Elena Steffensen, Kirstine Fleng Delaroche, Pierre Astoricchio, Emanuele Poulsen, Amalie Bech Brayson, Daniel Garibaldi, Fulvio Lanteri, Luca Pinali, Christian Valente, Giovanni Roppo Vignati, Federico Steffensen, John Fleng Shiels, Holly Tozzini, Eva Terzibasi Cellerino, Alessandro Animals Aging Sharks Male Myocardium Female Oxidative Stress Heart Lipofuscin Myocytes, Cardiac The Greenland shark (Somniosus microcephalus), with a lifespan estimated around 300 years, represents a unique model for studying vertebrate longevity. Here, we characterize its cardiac aging profile and compare it with two other species: the deep-sea shark Etmopterus spinax and the short-lived teleost Nothobranchius furzeri. Histological analysis revealed extensive interstitial and perivascular fibrosis throughout the ventricular myocardium of S. microcephalus, affecting both compact and spongy layers of both sexes. This fibrotic pattern was absent in E. spinax and N. furzeri, suggesting it is a specific feature of S. microcephalus. We also observed extreme lipofuscin accumulation within cardiomyocytes of S. microcephalus, which correlates at the ultrastructural level with the abundance of damaged mitochondria and the presence of strikingly enlarged lysosomes filled with electrondense material of likely mitochondrial origin. Additionally, in the myocardium of S. microcephalus we found abundant deposition of the oxidative stress marker 3-nitrotyrosine. Remarkably, despite showing multiple canonical markers of aging such as fibrosis, lipofuscin accumulation, and oxidative stress, S. microcephalus individuals appeared healthy and physiologically uncompromised at the time of capture. These findings suggest that S. microcephalus has evolved resilience to molecular and tissue-level aging signs and hallmarks, supporting sustained cardiac function over centuries and offering new insights into the mechanisms of extreme vertebrate longevity. |
| title | Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus. |
| topic | Animals Aging Sharks Male Myocardium Female Oxidative Stress Heart Lipofuscin Myocytes, Cardiac |
| url | https://pubmed.ncbi.nlm.nih.gov/42024652/ |