Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions.
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| Sprache: | en |
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BMC molecular and cell biology
2026
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| author | Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila |
| author_facet | Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila |
| collection | PubMed - marine biology |
| contents | Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions. Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila Animals Mesenchymal Stem Cells Osteogenesis Lipopolysaccharides Inflammation Rats Toll-Like Receptor 4 Sulfonamides Cell Differentiation Rats, Sprague-Dawley Male Cells, Cultured Tumor Necrosis Factor-alpha Immunologic Factors Interleukin-6 Bone regeneration involves a complex series of stages that need proper regulation of the acute inflammatory response. Toll-like receptor 4 (TLR4) is expressed in cells necessary for bone metabolism and modulates inflammatory conditions. However, excessive TLR4 activation can lead to immune dysregulation and decreased bone mineral deposition. This study investigates the effects of inhibiting TLR4 using TAK-242 on the osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs) under an acute inflammatory condition induced by lipopolysaccharide (LPS). BM-MSCs were obtained from rats, cultured, and evaluated to validate their characteristics. Subsequently, the cells were stimulated with LPS to induce an acute inflammatory model, followed by treatment with TAK-242 to assess its immunomodulatory effects on inflammatory responses, and osteogenic differentiation. TAK-242 exhibited significant anti-inflammatory effects on LPS-stimulated cells, with decreased expressions of IL-6 (p These findings emphasize the possible therapeutic use of TAK-242 in the field of osteoimmunology, particularly for treating inflammatory bone conditions. |
| format | Artículo científico |
| id | pubmed_42026458 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | BMC molecular and cell biology |
| record_format | pubmed |
| spellingShingle | Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions. Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila Animals Mesenchymal Stem Cells Osteogenesis Lipopolysaccharides Inflammation Rats Toll-Like Receptor 4 Sulfonamides Cell Differentiation Rats, Sprague-Dawley Male Cells, Cultured Tumor Necrosis Factor-alpha Immunologic Factors Interleukin-6 Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions. Ghiasvand, Mahsa Jouybari, Maryam Talebi Talkhabi, Mahmood Taghiyar, Leila Animals Mesenchymal Stem Cells Osteogenesis Lipopolysaccharides Inflammation Rats Toll-Like Receptor 4 Sulfonamides Cell Differentiation Rats, Sprague-Dawley Male Cells, Cultured Tumor Necrosis Factor-alpha Immunologic Factors Interleukin-6 Bone regeneration involves a complex series of stages that need proper regulation of the acute inflammatory response. Toll-like receptor 4 (TLR4) is expressed in cells necessary for bone metabolism and modulates inflammatory conditions. However, excessive TLR4 activation can lead to immune dysregulation and decreased bone mineral deposition. This study investigates the effects of inhibiting TLR4 using TAK-242 on the osteogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs) under an acute inflammatory condition induced by lipopolysaccharide (LPS). BM-MSCs were obtained from rats, cultured, and evaluated to validate their characteristics. Subsequently, the cells were stimulated with LPS to induce an acute inflammatory model, followed by treatment with TAK-242 to assess its immunomodulatory effects on inflammatory responses, and osteogenic differentiation. TAK-242 exhibited significant anti-inflammatory effects on LPS-stimulated cells, with decreased expressions of IL-6 (p These findings emphasize the possible therapeutic use of TAK-242 in the field of osteoimmunology, particularly for treating inflammatory bone conditions. |
| title | Immunomodulatory effects of TAK-242 on osteogenesis of mesenchymal stem cells in acute inflammatory conditions. |
| topic | Animals Mesenchymal Stem Cells Osteogenesis Lipopolysaccharides Inflammation Rats Toll-Like Receptor 4 Sulfonamides Cell Differentiation Rats, Sprague-Dawley Male Cells, Cultured Tumor Necrosis Factor-alpha Immunologic Factors Interleukin-6 |
| url | https://pubmed.ncbi.nlm.nih.gov/42026458/ |