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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Antibiotics (Basel, Switzerland)
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42041334/ |
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| _version_ | 1868266056165883906 |
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| author | Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata |
| author_facet | Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata |
| collection | PubMed - marine biology |
| contents | Screening of 44 Baltic Sea Cyanobacterial Strains for Antibacterial and Quorum Sensing Inhibitory Potential: Selection of Promising Candidates. Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata Cyanobacteria represent a diverse group of microorganisms capable of synthesizing a broad array of biologically active metabolites. Some of these compounds, believed to contribute to the ecological and evolutionary success of cyanobacteria, are increasingly being investigated for potential biomedical and biotechnological applications. They also hold promise in combating the growing threat of antimicrobial resistance (AMR). This screening study aimed to identify Baltic cyanobacterial strains with the potential to produce antibacterial compounds active against streptococci and mycobacteria, as well as quorum sensing inhibitors. Extracts from forty-four cyanobacterial strains were tested using a broth microdilution assay. The most pronounced activity was observed for extracts derived from two Pseudanabaenaceae strains (KUCC C3 and C4), two spp. strains (CCNP 1405 and CCNP 1406), and sp. KUCC C1. Inhibition of quorum sensing was the most frequently detected activity, with 30% of the tested extracts inhibiting violacein production in ATCC 12472. Growth inhibition of Gram-positive bacteria was less common: 16% of cyanobacterial strains inhibited ATCC 12344, and 11% inhibited ATCC 14468. Bioassay-guided fractionation of sp. KUCC C1, followed by LC-MS/MS analysis, revealed the presence of glycerolipids and glycolipids, including diacylglycerols (DAGs) and galactosyldiacylglycerols (MGDGs and DGDGs), as major constituents of fractions exhibiting quorum quenching activity. These findings highlight the potential of Baltic cyanobacteria as a source of natural compounds capable of disrupting bacterial communication and growth, offering prospects for the development of novel antimicrobial and anti-virulence agents. |
| format | Artículo científico |
| id | pubmed_42041334 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Antibiotics (Basel, Switzerland) |
| record_format | pubmed |
| spellingShingle | Screening of 44 Baltic Sea Cyanobacterial Strains for Antibacterial and Quorum Sensing Inhibitory Potential: Selection of Promising Candidates. Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata Screening of 44 Baltic Sea Cyanobacterial Strains for Antibacterial and Quorum Sensing Inhibitory Potential: Selection of Promising Candidates. Toruńska-Sitarz, Anna Konkel, Robert Ogrodnicka, Agnieszka Mazur-Marzec, Hanna Socha, Magdalena Overlingė, Donata Cyanobacteria represent a diverse group of microorganisms capable of synthesizing a broad array of biologically active metabolites. Some of these compounds, believed to contribute to the ecological and evolutionary success of cyanobacteria, are increasingly being investigated for potential biomedical and biotechnological applications. They also hold promise in combating the growing threat of antimicrobial resistance (AMR). This screening study aimed to identify Baltic cyanobacterial strains with the potential to produce antibacterial compounds active against streptococci and mycobacteria, as well as quorum sensing inhibitors. Extracts from forty-four cyanobacterial strains were tested using a broth microdilution assay. The most pronounced activity was observed for extracts derived from two Pseudanabaenaceae strains (KUCC C3 and C4), two spp. strains (CCNP 1405 and CCNP 1406), and sp. KUCC C1. Inhibition of quorum sensing was the most frequently detected activity, with 30% of the tested extracts inhibiting violacein production in ATCC 12472. Growth inhibition of Gram-positive bacteria was less common: 16% of cyanobacterial strains inhibited ATCC 12344, and 11% inhibited ATCC 14468. Bioassay-guided fractionation of sp. KUCC C1, followed by LC-MS/MS analysis, revealed the presence of glycerolipids and glycolipids, including diacylglycerols (DAGs) and galactosyldiacylglycerols (MGDGs and DGDGs), as major constituents of fractions exhibiting quorum quenching activity. These findings highlight the potential of Baltic cyanobacteria as a source of natural compounds capable of disrupting bacterial communication and growth, offering prospects for the development of novel antimicrobial and anti-virulence agents. |
| title | Screening of 44 Baltic Sea Cyanobacterial Strains for Antibacterial and Quorum Sensing Inhibitory Potential: Selection of Promising Candidates. |
| url | https://pubmed.ncbi.nlm.nih.gov/42041334/ |