Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes.
Fuente:
PubMed
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Cells
2026
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1868266056165883904 |
|---|---|
| author | Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth |
| author_facet | Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth |
| collection | PubMed - marine biology |
| contents | Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes. Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth Animals DNA Methylation Female Inflammation Mice Monocytes Brain Animals, Newborn DNA, Mitochondrial Pregnancy Epigenesis, Genetic Cell Nucleus Male Hypoxia-Ischemia, Brain CpG Islands Neonatal hypoxic ischemic encephalopathy (HIE) is a common birth complication that can cause death or lifelong disabling conditions like cerebral palsy, epilepsy, and autism. It is well established that maternal infection and inflammation are significant risk factors for HIE but reasons for this increase in neurological risk to the offspring remain unknown. Inflammation or infection are associated with epigenetic changes and may contribute to the increased risk of neurodevelopmental disability in exposed offspring. Here, we analyzed and compared DNA methylation patterns in brain monocytes isolated from control, maternal immune activation (MIA), and an inflammation sensitized HIE (IS-HIE) CF-1 mouse model at postnatal day 7. We found that maternal inflammation induced significant methylation differences in neonates relative to control samples in both MIA and IS-HIE samples with no significant differences identified between the MIA and IS-HIE groups. MIA samples showed hypermethylation at loci involving craniofacial development and transcription factors important for regulating neurodevelopment and immune function. MIA samples also demonstrated significant hypermethylation at multiple mitochondrial genome CpGs. These findings suggest that maternal inflammation induces epigenetic alterations in fetal brain immune cells that are detectable in neonates. These changes may contribute to heightened neurodevelopmental risk in offspring following hypoxic injury, highlighting potential molecular pathways for future therapeutic targeting. |
| format | Artículo científico |
| id | pubmed_42041581 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Cells |
| record_format | pubmed |
| spellingShingle | Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes. Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth Animals DNA Methylation Female Inflammation Mice Monocytes Brain Animals, Newborn DNA, Mitochondrial Pregnancy Epigenesis, Genetic Cell Nucleus Male Hypoxia-Ischemia, Brain CpG Islands Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes. Ebenezer, Andrew T Hicks, Jonathan R Hollander, Brooke Hone, Alexander Batish, Mona Akins, Robert Marsh, Adam Wright-Jin, Elizabeth Animals DNA Methylation Female Inflammation Mice Monocytes Brain Animals, Newborn DNA, Mitochondrial Pregnancy Epigenesis, Genetic Cell Nucleus Male Hypoxia-Ischemia, Brain CpG Islands Neonatal hypoxic ischemic encephalopathy (HIE) is a common birth complication that can cause death or lifelong disabling conditions like cerebral palsy, epilepsy, and autism. It is well established that maternal infection and inflammation are significant risk factors for HIE but reasons for this increase in neurological risk to the offspring remain unknown. Inflammation or infection are associated with epigenetic changes and may contribute to the increased risk of neurodevelopmental disability in exposed offspring. Here, we analyzed and compared DNA methylation patterns in brain monocytes isolated from control, maternal immune activation (MIA), and an inflammation sensitized HIE (IS-HIE) CF-1 mouse model at postnatal day 7. We found that maternal inflammation induced significant methylation differences in neonates relative to control samples in both MIA and IS-HIE samples with no significant differences identified between the MIA and IS-HIE groups. MIA samples showed hypermethylation at loci involving craniofacial development and transcription factors important for regulating neurodevelopment and immune function. MIA samples also demonstrated significant hypermethylation at multiple mitochondrial genome CpGs. These findings suggest that maternal inflammation induces epigenetic alterations in fetal brain immune cells that are detectable in neonates. These changes may contribute to heightened neurodevelopmental risk in offspring following hypoxic injury, highlighting potential molecular pathways for future therapeutic targeting. |
| title | Maternal Inflammation Alters Nuclear and Mitochondrial DNA Methylation Patterns in Neonatal Brain Monocytes. |
| topic | Animals DNA Methylation Female Inflammation Mice Monocytes Brain Animals, Newborn DNA, Mitochondrial Pregnancy Epigenesis, Genetic Cell Nucleus Male Hypoxia-Ischemia, Brain CpG Islands |
| url | https://pubmed.ncbi.nlm.nih.gov/42041581/ |