Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2.
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
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Bioorganic chemistry
2026
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| _version_ | 1868266056159592448 |
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| author | Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun |
| author_facet | Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun |
| collection | PubMed - marine biology |
| contents | Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2. Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun Humans Mitophagy Autophagy Depsipeptides Molecular Structure Structure-Activity Relationship Dose-Response Relationship, Drug Alzheimer Disease Amyloid beta-Peptides Dysregulation of autophagy and mitophagy is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD). Chemical intervention targeting these pathways has emerged as one of the promising therapeutic strategies for neurodegenerative disorders. Here, we identified beauvericin as a candidate molecule that regulates autophagy and mitophagy through an organelle phenotypes-based high-throughput screening of a marine natural products library. Mechanistic analyses revealed that beauvericin engages NIPSNAP2 and promotes its activation, and enhances autophagic flux and mitophagy across multiple cell types. Moreover, in AD-relevant cellular models, beauvericin significantly reduced amyloid-β (Aβ) levels via lysosome-dependent degradation of BACE1. Collectively, these findings demonstrate that beauvericin activates autophagy and mitophagy via NIPSNAP2 and that chemical activation of these pathways can ameliorate AD-relevant cellular phenotypes, supporting its potential as a chemical intervention for neurodegenerative diseases. |
| format | Artículo científico |
| id | pubmed_42044561 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Bioorganic chemistry |
| record_format | pubmed |
| spellingShingle | Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2. Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun Humans Mitophagy Autophagy Depsipeptides Molecular Structure Structure-Activity Relationship Dose-Response Relationship, Drug Alzheimer Disease Amyloid beta-Peptides Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2. Zhao, Xue Zhang, Ruihan Ma, Yihan Yu, Ting Li, Jiao Liu, Andi Hu, Junchi Wu, Jiaxue Zhang, Ling Ye, Mingliang Wu, Bin Dang, Yongjun Humans Mitophagy Autophagy Depsipeptides Molecular Structure Structure-Activity Relationship Dose-Response Relationship, Drug Alzheimer Disease Amyloid beta-Peptides Dysregulation of autophagy and mitophagy is a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD). Chemical intervention targeting these pathways has emerged as one of the promising therapeutic strategies for neurodegenerative disorders. Here, we identified beauvericin as a candidate molecule that regulates autophagy and mitophagy through an organelle phenotypes-based high-throughput screening of a marine natural products library. Mechanistic analyses revealed that beauvericin engages NIPSNAP2 and promotes its activation, and enhances autophagic flux and mitophagy across multiple cell types. Moreover, in AD-relevant cellular models, beauvericin significantly reduced amyloid-β (Aβ) levels via lysosome-dependent degradation of BACE1. Collectively, these findings demonstrate that beauvericin activates autophagy and mitophagy via NIPSNAP2 and that chemical activation of these pathways can ameliorate AD-relevant cellular phenotypes, supporting its potential as a chemical intervention for neurodegenerative diseases. |
| title | Beauvericin promotes autophagy and mitophagy by activating NIPSNAP2. |
| topic | Humans Mitophagy Autophagy Depsipeptides Molecular Structure Structure-Activity Relationship Dose-Response Relationship, Drug Alzheimer Disease Amyloid beta-Peptides |
| url | https://pubmed.ncbi.nlm.nih.gov/42044561/ |