Stage-resolved multi-tissue transcriptomics reveals coordinated molecular responses during feeding in Babylonia areolata.
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| Autores principales: | , , , , , , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Comparative biochemistry and physiology. Part D, Genomics & proteomics
2026
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| _version_ | 1868266053609455616 |
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| author | Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng |
| author_facet | Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng |
| collection | PubMed - marine biology |
| contents | Stage-resolved multi-tissue transcriptomics reveals coordinated molecular responses during feeding in Babylonia areolata. Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng Animals Transcriptome Feeding Behavior Gastropoda Gene Expression Profiling Feeding is a fundamental physiological process in mollusks and requires coordinated sensory, neural, and metabolic responses across multiple tissues. However, the cross-tissue molecular mechanisms underlying feeding in gastropods remain largely unexplored. In this study, we conducted a multi-tissue comparative transcriptomic analysis of Babylonia areolata across four key feeding stages, including pre-feeding, feeding initiation, satiation, and post-feeding, to characterize dynamic molecular responses in the osphradium, cephalic region, and hepatopancreas. Integrated analyses of differential expression, functional enrichment, and weighted gene co-expression network analysis (WGCNA) were used to reconstruct a cross-tissue regulatory framework. Feeding triggered distinct yet temporally coordinated transcriptional programs across tissues. The osphradium showed rapid activation of neuroactive ligand-receptor interaction, calcium signaling, and Wnt pathways, supporting its role as the primary chemosensory gateway that converts food-derived cues into neural signals. The cephalic region exhibited multi-phasic neuroactive and Wnt signaling responses, corresponding to phases of sensory readiness, neural activation, and post-feeding modulation. In contrast, the hepatopancreas displayed a stage-specific metabolic progression, transitioning from lysosomal digestive activation to enhanced amino acid and nucleotide biosynthesis, followed by lipid remodeling, antioxidant defense, and immune regulation during the post-feeding period. Together, these results reveal a hierarchical "sensing-integration-execution" cascade that links chemosensory perception to neural processing and metabolic execution during feeding. This study provides the first cross-tissue molecular atlas of feeding regulation in B. areolata, offering new insights into neuro-metabolic integration in gastropods and informing feed optimization and health-oriented aquaculture strategies. |
| format | Artículo científico |
| id | pubmed_42048951 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Part D, Genomics & proteomics |
| record_format | pubmed |
| spellingShingle | Stage-resolved multi-tissue transcriptomics reveals coordinated molecular responses during feeding in Babylonia areolata. Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng Animals Transcriptome Feeding Behavior Gastropoda Gene Expression Profiling Stage-resolved multi-tissue transcriptomics reveals coordinated molecular responses during feeding in Babylonia areolata. Hong, Xin Ren, Peng Huang, Yulu Chen, Wenqi Zhang, Ye Yu, Feng Yang, Yi Wang, Aimin Liu, Chunsheng Animals Transcriptome Feeding Behavior Gastropoda Gene Expression Profiling Feeding is a fundamental physiological process in mollusks and requires coordinated sensory, neural, and metabolic responses across multiple tissues. However, the cross-tissue molecular mechanisms underlying feeding in gastropods remain largely unexplored. In this study, we conducted a multi-tissue comparative transcriptomic analysis of Babylonia areolata across four key feeding stages, including pre-feeding, feeding initiation, satiation, and post-feeding, to characterize dynamic molecular responses in the osphradium, cephalic region, and hepatopancreas. Integrated analyses of differential expression, functional enrichment, and weighted gene co-expression network analysis (WGCNA) were used to reconstruct a cross-tissue regulatory framework. Feeding triggered distinct yet temporally coordinated transcriptional programs across tissues. The osphradium showed rapid activation of neuroactive ligand-receptor interaction, calcium signaling, and Wnt pathways, supporting its role as the primary chemosensory gateway that converts food-derived cues into neural signals. The cephalic region exhibited multi-phasic neuroactive and Wnt signaling responses, corresponding to phases of sensory readiness, neural activation, and post-feeding modulation. In contrast, the hepatopancreas displayed a stage-specific metabolic progression, transitioning from lysosomal digestive activation to enhanced amino acid and nucleotide biosynthesis, followed by lipid remodeling, antioxidant defense, and immune regulation during the post-feeding period. Together, these results reveal a hierarchical "sensing-integration-execution" cascade that links chemosensory perception to neural processing and metabolic execution during feeding. This study provides the first cross-tissue molecular atlas of feeding regulation in B. areolata, offering new insights into neuro-metabolic integration in gastropods and informing feed optimization and health-oriented aquaculture strategies. |
| title | Stage-resolved multi-tissue transcriptomics reveals coordinated molecular responses during feeding in Babylonia areolata. |
| topic | Animals Transcriptome Feeding Behavior Gastropoda Gene Expression Profiling |
| url | https://pubmed.ncbi.nlm.nih.gov/42048951/ |