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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42061665/ |
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| _version_ | 1868266053591629827 |
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| author | Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N |
| author_facet | Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N |
| collection | PubMed - marine biology |
| contents | Bioaccumulation and elimination kinetics of metals and polycyclic aromatic hydrocarbons in Hermetia illucens larvae: Implications for risk mitigation of selected contaminants in insect farming. Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N Animals Larva Polycyclic Aromatic Hydrocarbons Diptera Bioaccumulation Kinetics Half-Life Metals Rapidly expanding insect farming industries worldwide are raising concerns about introducing contaminants into food chains. One of the dominant species in this new bioindustry, the black soldier fly (Hermetia illucens), offers diverse benefits ranging from protein production to waste management, biofuel, and pharmaceutical applications. Recent studies have highlighted the ability of insects to accumulate metals; however, knowledge of their ability to eliminate contaminants is needed. Similarly, information regarding the accumulation of polycyclic aromatic hydrocarbons (PAHs) is lacking. This study aimed to understand how H. illucens larvae accumulate and eliminate metals and PAHs from contaminated substrates. We performed two-phase bioaccumulation experiments followed by toxicokinetic modelling to estimate uptake and elimination rate constants and half-lives in H. illucens. During the uptake phase, insects were exposed for five days to contaminated substrates at EU maximum feed concentrations: 2 mg kg for As and Cd, 10 mg kg for Pb, and 12.5 μg kg for each of four PAHs (benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, chrysene). In the second phase, insects were exposed to non-contaminated substrates for five days to evaluate elimination. Results showed metal accumulation with kinetic bioaccumulation factors of 4.26, 1.16, and 1.31 for Cd, As, and Pb, respectively. A one-day depuration reduced As and Pb below regulatory thresholds; Cd required three days. Minimal to no accumulation was observed for B[a]P and B[b]F, with higher uptake for B[a]A. PAH half-lives were under one day. These findings, from controlled experiments with limited contaminants, support incorporating a depuration phase for risk mitigation in H. illucens waste-to-protein systems. |
| format | Artículo científico |
| id | pubmed_42061665 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP |
| record_format | pubmed |
| spellingShingle | Bioaccumulation and elimination kinetics of metals and polycyclic aromatic hydrocarbons in Hermetia illucens larvae: Implications for risk mitigation of selected contaminants in insect farming. Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N Animals Larva Polycyclic Aromatic Hydrocarbons Diptera Bioaccumulation Kinetics Half-Life Metals Bioaccumulation and elimination kinetics of metals and polycyclic aromatic hydrocarbons in Hermetia illucens larvae: Implications for risk mitigation of selected contaminants in insect farming. Mostafaie, Amid Silva, Patricia V Prodana, Marija Silva, Ana Rita R Pinto, José N Duarte, Regina M B O Alvito, Paula Coelho, Inês Rego, Andreia Lopes, Iva G Brooks, Bryan W Loureiro, Susana Cardoso, Diogo N Animals Larva Polycyclic Aromatic Hydrocarbons Diptera Bioaccumulation Kinetics Half-Life Metals Rapidly expanding insect farming industries worldwide are raising concerns about introducing contaminants into food chains. One of the dominant species in this new bioindustry, the black soldier fly (Hermetia illucens), offers diverse benefits ranging from protein production to waste management, biofuel, and pharmaceutical applications. Recent studies have highlighted the ability of insects to accumulate metals; however, knowledge of their ability to eliminate contaminants is needed. Similarly, information regarding the accumulation of polycyclic aromatic hydrocarbons (PAHs) is lacking. This study aimed to understand how H. illucens larvae accumulate and eliminate metals and PAHs from contaminated substrates. We performed two-phase bioaccumulation experiments followed by toxicokinetic modelling to estimate uptake and elimination rate constants and half-lives in H. illucens. During the uptake phase, insects were exposed for five days to contaminated substrates at EU maximum feed concentrations: 2 mg kg for As and Cd, 10 mg kg for Pb, and 12.5 μg kg for each of four PAHs (benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, chrysene). In the second phase, insects were exposed to non-contaminated substrates for five days to evaluate elimination. Results showed metal accumulation with kinetic bioaccumulation factors of 4.26, 1.16, and 1.31 for Cd, As, and Pb, respectively. A one-day depuration reduced As and Pb below regulatory thresholds; Cd required three days. Minimal to no accumulation was observed for B[a]P and B[b]F, with higher uptake for B[a]A. PAH half-lives were under one day. These findings, from controlled experiments with limited contaminants, support incorporating a depuration phase for risk mitigation in H. illucens waste-to-protein systems. |
| title | Bioaccumulation and elimination kinetics of metals and polycyclic aromatic hydrocarbons in Hermetia illucens larvae: Implications for risk mitigation of selected contaminants in insect farming. |
| topic | Animals Larva Polycyclic Aromatic Hydrocarbons Diptera Bioaccumulation Kinetics Half-Life Metals |
| url | https://pubmed.ncbi.nlm.nih.gov/42061665/ |