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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Microorganisms
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42075320/ |
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| _version_ | 1868266053579046913 |
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| author | Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário |
| author_facet | Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário |
| collection | PubMed - marine biology |
| contents | Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications. Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário The increase in multidrug resistance in microorganisms and the rise of emergent infectious diseases worldwide is a threat to human and animal health. Therefore, research on new molecules with antibiotic potential is a priority. Lichens have a unique secondary metabolism with relatively untapped potential, yet their essential oils (EOs) and volatile organic compounds (VOCs) remain a relatively untapped resource. This systematic review was conducted following PRISMA 2020 guidelines, with a comprehensive search performed in the Web of Science database for studies published up to 2023. From 254 identified records, six studies involving nine lichen species (, , , , , , , , and ) met the eligibility criteria. The synthesized data show that these volatile fractions possess significant antimicrobial potential, with minimum inhibitory concentrations (MICs) generally lower than 1 mg/mL. Major bioactive constituents identified include atraric acid, orsellinates, and various sesquiterpenes. While the current evidence highlights a strong potential of lichen volatiles against pathogens, research is limited to a small fraction of known species. This review identifies a critical gap in testing these compounds directly against MDR clinical isolates and suggests that future research should focus on high-biomass species and the heterologous expression of lichen biosynthetic genes to develop sustainable antimicrobial applications. |
| format | Artículo científico |
| id | pubmed_42075320 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Microorganisms |
| record_format | pubmed |
| spellingShingle | Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications. Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications. Essadki, Yasser Zerrifi, Soukaina El Amrani Carvalho, Maria de Fátima Barros, Lillian Vasconcelos, Vitor Campos, Alexandre Khalloufi, Fatima El Oudra, Brahim Martins, Rosário The increase in multidrug resistance in microorganisms and the rise of emergent infectious diseases worldwide is a threat to human and animal health. Therefore, research on new molecules with antibiotic potential is a priority. Lichens have a unique secondary metabolism with relatively untapped potential, yet their essential oils (EOs) and volatile organic compounds (VOCs) remain a relatively untapped resource. This systematic review was conducted following PRISMA 2020 guidelines, with a comprehensive search performed in the Web of Science database for studies published up to 2023. From 254 identified records, six studies involving nine lichen species (, , , , , , , , and ) met the eligibility criteria. The synthesized data show that these volatile fractions possess significant antimicrobial potential, with minimum inhibitory concentrations (MICs) generally lower than 1 mg/mL. Major bioactive constituents identified include atraric acid, orsellinates, and various sesquiterpenes. While the current evidence highlights a strong potential of lichen volatiles against pathogens, research is limited to a small fraction of known species. This review identifies a critical gap in testing these compounds directly against MDR clinical isolates and suggests that future research should focus on high-biomass species and the heterologous expression of lichen biosynthetic genes to develop sustainable antimicrobial applications. |
| title | Unveiling Lichen's Hidden Arsenal Against Multidrug Resistance: A Systematic Review of Their Essential Oils, Volatile Compounds and Extracts with Antimicrobial Applications. |
| url | https://pubmed.ncbi.nlm.nih.gov/42075320/ |