Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469.
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| Autores principales: | , , , |
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Chemistry & biodiversity
2026
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| _version_ | 1868266053568561152 |
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| author | Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong |
| author_facet | Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong |
| collection | PubMed - marine biology |
| contents | Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469. Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong Talaromyces Polyketides Microbial Sensitivity Tests Anti-Bacterial Agents Molecular Structure Crystallography, X-Ray Vibrio Molecular Conformation Structure-Activity Relationship Models, Molecular Dose-Response Relationship, Drug Three novel polyketides, talaroindiones A-C (1-3), along with two known diphenyl ether derivatives (4 and 5) were isolated from the rice culture medium extract of the marine-derived fungus Talaromyces indigoticus CS-469. The structures of 1-3 were determined by comprehensive spectroscopic analysis and confirmed by single-crystal x-ray diffraction. Their absolute configurations were assigned using TDDFT-ECD calculations, while those of 4 and 5 were established by comparison of their experimental optical rotations with literature values. All compounds were evaluated for their antibacterial activity. Compound 4 exhibited broad-spectrum inhibitory activities against six bacterial strains, showing particularly potent activity against Vibrio harveyi and Vibrio parahaemolyticus with MIC values of 2 µg/mL. |
| format | Artículo científico |
| id | pubmed_42081617 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Chemistry & biodiversity |
| record_format | pubmed |
| spellingShingle | Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469. Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong Talaromyces Polyketides Microbial Sensitivity Tests Anti-Bacterial Agents Molecular Structure Crystallography, X-Ray Vibrio Molecular Conformation Structure-Activity Relationship Models, Molecular Dose-Response Relationship, Drug Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469. Deng, Ruo-Xi Li, Xiao-Ming Wang, Bin-Gui Meng, Ling-Hong Talaromyces Polyketides Microbial Sensitivity Tests Anti-Bacterial Agents Molecular Structure Crystallography, X-Ray Vibrio Molecular Conformation Structure-Activity Relationship Models, Molecular Dose-Response Relationship, Drug Three novel polyketides, talaroindiones A-C (1-3), along with two known diphenyl ether derivatives (4 and 5) were isolated from the rice culture medium extract of the marine-derived fungus Talaromyces indigoticus CS-469. The structures of 1-3 were determined by comprehensive spectroscopic analysis and confirmed by single-crystal x-ray diffraction. Their absolute configurations were assigned using TDDFT-ECD calculations, while those of 4 and 5 were established by comparison of their experimental optical rotations with literature values. All compounds were evaluated for their antibacterial activity. Compound 4 exhibited broad-spectrum inhibitory activities against six bacterial strains, showing particularly potent activity against Vibrio harveyi and Vibrio parahaemolyticus with MIC values of 2 µg/mL. |
| title | Talaroindiones A-C, New Polyketides Characterized From the Cold-Seep-Derived Talaromyces indigoticus CS-469. |
| topic | Talaromyces Polyketides Microbial Sensitivity Tests Anti-Bacterial Agents Molecular Structure Crystallography, X-Ray Vibrio Molecular Conformation Structure-Activity Relationship Models, Molecular Dose-Response Relationship, Drug |
| url | https://pubmed.ncbi.nlm.nih.gov/42081617/ |