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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
bioRxiv : the preprint server for biology
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42094583/ |
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| _version_ | 1868266051118039043 |
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| author | Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K |
| author_facet | Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K |
| collection | PubMed - marine biology |
| contents | Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations. Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K Population-specific immunity can drive variation in infection outcomes, but studying immune variation in the wild is challenging because exposure histories are unknown. Comparing wild populations with those reared in a common environment can disentangle genetic and environmental drivers of immunity. We applied this approach in freshwater threespine stickleback, where populations vary in their use of intraperitoneal fibrosis to defend against the helminth parasite . We combined a 46-lake immune survey with a common garden experiment using 20 representative populations to examine variation in fibrosis and infection. Laboratory assays included exposures to live tapeworms and immune challenges with tapeworm proteins and aluminum phosphate (Alum). We found heritable variation in both constitutive fibrosis and inducible fibrosis. Inducible responses to tapeworms were associated with lake environmental conditions, with fish from more eutrophic-like lakes showing stronger fibrosis induction than those from more oligotrophic-like lakes. Together, these results show how integrating wild immune variation with common garden experiments can reveal novel heritable defenses and link their evolution to ecological variation. |
| format | Artículo científico |
| id | pubmed_42094583 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | bioRxiv : the preprint server for biology |
| record_format | pubmed |
| spellingShingle | Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations. Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations. Choi, Emma S Flanagan, Ben A Alexander, Heather Berini, John Yeung, Alex Wolf, Cole J Watts, Viola Vaziri, Grace Vargas, Nataly Szajada, Caroline Steffen, Penelope Srinivas, Ipsita Shahid, Mehreen Santacruz, Ana Rochon, Kaligua Rippin, Luke Reyes Contreras, Edith Redfield, Emma Polard, Emma Patterson, Cate Gilani, Fahad Flanagan, Julian Dubin, Shira Cooper, Peaches Codner, Panna Chen, Amy Casey, Gwen Albright, Abigail G Hite, Jessica Weber, Jesse N Bolnick, Daniel I Hund, Amanda K Population-specific immunity can drive variation in infection outcomes, but studying immune variation in the wild is challenging because exposure histories are unknown. Comparing wild populations with those reared in a common environment can disentangle genetic and environmental drivers of immunity. We applied this approach in freshwater threespine stickleback, where populations vary in their use of intraperitoneal fibrosis to defend against the helminth parasite . We combined a 46-lake immune survey with a common garden experiment using 20 representative populations to examine variation in fibrosis and infection. Laboratory assays included exposures to live tapeworms and immune challenges with tapeworm proteins and aluminum phosphate (Alum). We found heritable variation in both constitutive fibrosis and inducible fibrosis. Inducible responses to tapeworms were associated with lake environmental conditions, with fish from more eutrophic-like lakes showing stronger fibrosis induction than those from more oligotrophic-like lakes. Together, these results show how integrating wild immune variation with common garden experiments can reveal novel heritable defenses and link their evolution to ecological variation. |
| title | Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations. |
| url | https://pubmed.ncbi.nlm.nih.gov/42094583/ |