A novel monoterpene indole alkaloid from Roxb. and its antitumor activity and action mechanism.
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| Main Authors: | , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Natural product research
2026
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| _version_ | 1868266051101261825 |
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| author | Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao |
| author_facet | Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao |
| collection | PubMed - marine biology |
| contents | A novel monoterpene indole alkaloid from Roxb. and its antitumor activity and action mechanism. Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao Roxb. () remains largely unexplored in chemical constituents and antitumor bioactivities. Ten compounds were isolated and structurally elucidated from the hooked stems and branches of . Herein, a novel compound was identified through various spectroscopic analyses. antitumor assays revealed that compound exhibited broad-spectrum antiproliferative activity against six tumour cell lines, with potent efficacy against HL-60 (IC = 8.21 μM) and HeLa (IC = 9.04 μM) cells, while showing low cytotoxicity towards L02 human normal liver cells (IC > 40 μM). Network pharmacology analysis revealed that the enriched signalling pathways of compound are mainly the MAPK and PI3K-AKT pathways, closely associated with the progression of leukaemia and cervical cancer. Molecular docking confirmed the stable binding of compound to B-cell lymphoma 2 (BCL-2) and mitogen-activated protein kinase kinase 1 (MAP2K1) with binding free energies of -8.9 kcal mol and -9.6 kcal mol, respectively. Overall, these results elucidate the dual antitumor mechanisms of compound , demonstrating its potential as a lead candidate for treating leukaemia and cervical cancer. |
| format | Artículo científico |
| id | pubmed_42104680 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Natural product research |
| record_format | pubmed |
| spellingShingle | A novel monoterpene indole alkaloid from Roxb. and its antitumor activity and action mechanism. Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao A novel monoterpene indole alkaloid from Roxb. and its antitumor activity and action mechanism. Huang, Li Liu, Wenyan Li, Xinyue Li, Zheng Nan, Xiang Wang, Wei Wang, Ziming Jin, Song Wu, Yanchao Roxb. () remains largely unexplored in chemical constituents and antitumor bioactivities. Ten compounds were isolated and structurally elucidated from the hooked stems and branches of . Herein, a novel compound was identified through various spectroscopic analyses. antitumor assays revealed that compound exhibited broad-spectrum antiproliferative activity against six tumour cell lines, with potent efficacy against HL-60 (IC = 8.21 μM) and HeLa (IC = 9.04 μM) cells, while showing low cytotoxicity towards L02 human normal liver cells (IC > 40 μM). Network pharmacology analysis revealed that the enriched signalling pathways of compound are mainly the MAPK and PI3K-AKT pathways, closely associated with the progression of leukaemia and cervical cancer. Molecular docking confirmed the stable binding of compound to B-cell lymphoma 2 (BCL-2) and mitogen-activated protein kinase kinase 1 (MAP2K1) with binding free energies of -8.9 kcal mol and -9.6 kcal mol, respectively. Overall, these results elucidate the dual antitumor mechanisms of compound , demonstrating its potential as a lead candidate for treating leukaemia and cervical cancer. |
| title | A novel monoterpene indole alkaloid from Roxb. and its antitumor activity and action mechanism. |
| url | https://pubmed.ncbi.nlm.nih.gov/42104680/ |