Seasonal metabolite profiling of Thyone aurea from Saldanha Bay, South Africa.
Fuente:
PubMed
Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Comparative biochemistry and physiology. Part D, Genomics & proteomics
2026
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1868266048912883712 |
|---|---|
| author | Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses |
| author_facet | Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses |
| collection | PubMed - marine biology |
| contents | Seasonal metabolite profiling of Thyone aurea from Saldanha Bay, South Africa. Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses Animals South Africa Seasons Metabolome Metabolomics Sea Cucumbers Tandem Mass Spectrometry Bays The pursuit of natural therapeutic drugs has fuelled interest in metabolomics, particularly marine metabolomics, with sea cucumbers standing out for their high nutritional value and potential for bioactive metabolites. However, limited research, especially in Southern Africa, has resulted in significant knowledge gaps regarding the value of lesser-known species, contributing to the exploitation of select high-value species due to rising market demand for holothurian products. This study aimed to address these gaps by characterising the metabolic profile of three body tissue extracts-body wall, gonad, and gut/mesentery-from Thyone aurea, an endemic species found along the Western Coast of Southern Africa, using untargeted H NMR metabolomics and full-scan UPLC-QTOF-MS/MS. The results revealed a diverse array of amino acids, sugars, and organic acids, with the gut/mesentery tissue and spring-summer extracts exhibiting the highest potential for variable metabolites. However, these patterns represent relative signatures requiring further validation with fresh tissues. While some compounds may be integral to sea cucumber physiology, the origin of others remains unclear, warranting further research into holothurian metabolic pathways and the potential impact of dietary sources and microbial activity on the metabolome. Therefore, this study emphasises the importance of expanding research to understand the metabolic responses to environmental changes, which could offer valuable insights to support conservation and sustainable cultivation strategies. Moreover, these findings underscore the need to explore lesser-known species as alternative resources in cultivation strategies to promote sustainable holothurian resources for commercial, pharmaceutical, and nutritional applications. Overall, this research enhances our understanding of sea cucumber biology and underscores the importance of incorporating a broader range of species in scientific research. |
| format | Artículo científico |
| id | pubmed_42140138 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Comparative biochemistry and physiology. Part D, Genomics & proteomics |
| record_format | pubmed |
| spellingShingle | Seasonal metabolite profiling of Thyone aurea from Saldanha Bay, South Africa. Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses Animals South Africa Seasons Metabolome Metabolomics Sea Cucumbers Tandem Mass Spectrometry Bays Seasonal metabolite profiling of Thyone aurea from Saldanha Bay, South Africa. Upton, Cassandra Prinsloo, Gerhard Steenkamp, Paul Anton Okpeku, Moses Animals South Africa Seasons Metabolome Metabolomics Sea Cucumbers Tandem Mass Spectrometry Bays The pursuit of natural therapeutic drugs has fuelled interest in metabolomics, particularly marine metabolomics, with sea cucumbers standing out for their high nutritional value and potential for bioactive metabolites. However, limited research, especially in Southern Africa, has resulted in significant knowledge gaps regarding the value of lesser-known species, contributing to the exploitation of select high-value species due to rising market demand for holothurian products. This study aimed to address these gaps by characterising the metabolic profile of three body tissue extracts-body wall, gonad, and gut/mesentery-from Thyone aurea, an endemic species found along the Western Coast of Southern Africa, using untargeted H NMR metabolomics and full-scan UPLC-QTOF-MS/MS. The results revealed a diverse array of amino acids, sugars, and organic acids, with the gut/mesentery tissue and spring-summer extracts exhibiting the highest potential for variable metabolites. However, these patterns represent relative signatures requiring further validation with fresh tissues. While some compounds may be integral to sea cucumber physiology, the origin of others remains unclear, warranting further research into holothurian metabolic pathways and the potential impact of dietary sources and microbial activity on the metabolome. Therefore, this study emphasises the importance of expanding research to understand the metabolic responses to environmental changes, which could offer valuable insights to support conservation and sustainable cultivation strategies. Moreover, these findings underscore the need to explore lesser-known species as alternative resources in cultivation strategies to promote sustainable holothurian resources for commercial, pharmaceutical, and nutritional applications. Overall, this research enhances our understanding of sea cucumber biology and underscores the importance of incorporating a broader range of species in scientific research. |
| title | Seasonal metabolite profiling of Thyone aurea from Saldanha Bay, South Africa. |
| topic | Animals South Africa Seasons Metabolome Metabolomics Sea Cucumbers Tandem Mass Spectrometry Bays |
| url | https://pubmed.ncbi.nlm.nih.gov/42140138/ |