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| Format: | Artículo científico |
| Sprache: | en |
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International journal of biological macromolecules
2026
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/42140302/ |
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| author | Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha |
| author_facet | Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha |
| collection | PubMed - marine biology |
| contents | Ultrasound-assisted valorization of Posidonia oceanica polysaccharides: Discovery of novel monosaccharides and enhanced multifunctional bioactivity. Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha Polysaccharides Alismatales Monosaccharides Plant Leaves Antioxidants Antiviral Agents Humans Ultrasonic Waves Molecular Weight Herpesvirus 2, Human Rhizome Posidonia oceanica, a Mediterranean seagrass, represents a promising marine resource for the production of high-value polysaccharides with potential industrial and biomedical applications. In this study, ultrasound-assisted extraction (UAE) was deliberately applied under non-optimized conditions to investigate its impact on the structure of polysaccharides obtained from P. oceanica leaves (MKF) and rhizomes (MKR), yielding 0.63% and 0.43% (w/w), respectively. GC-MS analysis of MKF revealed a diverse monosaccharide profile, including xylose (22.7%), arabinose (21.7%), glucose (16.3%), rhamnose (13.2%), and, for the first time in Posidonia oceanica, tentatively identified talose (7.2%), lyxose (7.7%), and fucose (4.0%). Molecular weight determination via size-exclusion Chromatography showed 394,000 g·mol for MKF and 180,000 g·mol for MKR. Leaf-derived polysaccharides exhibited significantly stronger antioxidant activity (DPPH IC₅₀ = 10.91 ± 0.70 μg/mL; ABTS IC₅₀ = 6.78 ± 0.07 μg/mL) compared to rhizome extracts. Both extracts demonstrated high photoprotective potential (SPF = 42.3 and 39.3 for MKF and MKR, respectively) and substantial antiviral potency toward type 2 herpes simplex virus, with selectivity indices of 750-850 and no detectable cytotoxicity up to 2500 μg/mL. These results suggest that ultrasound-induced structural modifications enhance the bioactivity of P. oceanica polysaccharides, positioning them as multifunctional biomolecules with potential applications in pharmaceuticals, cosmeceuticals, and other industrial sectors. |
| format | Artículo científico |
| id | pubmed_42140302 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of biological macromolecules |
| record_format | pubmed |
| spellingShingle | Ultrasound-assisted valorization of Posidonia oceanica polysaccharides: Discovery of novel monosaccharides and enhanced multifunctional bioactivity. Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha Polysaccharides Alismatales Monosaccharides Plant Leaves Antioxidants Antiviral Agents Humans Ultrasonic Waves Molecular Weight Herpesvirus 2, Human Rhizome Ultrasound-assisted valorization of Posidonia oceanica polysaccharides: Discovery of novel monosaccharides and enhanced multifunctional bioactivity. Malaoui, Karima Ben Haj Mbarek, Asma Karouche, Saida Itaimi Dammak, Mariem Majdoub, Hatem Le Cerf, Didier Bendif, Hamdi Taha, Tarek H Elfalleh, Walid Ali, Mohamed A M Yildiz, Ilyas Bouslama, Lamjed Bensouici, Chawki Laichi, Yacine Garzoli, Stefania Laouani, Aicha Polysaccharides Alismatales Monosaccharides Plant Leaves Antioxidants Antiviral Agents Humans Ultrasonic Waves Molecular Weight Herpesvirus 2, Human Rhizome Posidonia oceanica, a Mediterranean seagrass, represents a promising marine resource for the production of high-value polysaccharides with potential industrial and biomedical applications. In this study, ultrasound-assisted extraction (UAE) was deliberately applied under non-optimized conditions to investigate its impact on the structure of polysaccharides obtained from P. oceanica leaves (MKF) and rhizomes (MKR), yielding 0.63% and 0.43% (w/w), respectively. GC-MS analysis of MKF revealed a diverse monosaccharide profile, including xylose (22.7%), arabinose (21.7%), glucose (16.3%), rhamnose (13.2%), and, for the first time in Posidonia oceanica, tentatively identified talose (7.2%), lyxose (7.7%), and fucose (4.0%). Molecular weight determination via size-exclusion Chromatography showed 394,000 g·mol for MKF and 180,000 g·mol for MKR. Leaf-derived polysaccharides exhibited significantly stronger antioxidant activity (DPPH IC₅₀ = 10.91 ± 0.70 μg/mL; ABTS IC₅₀ = 6.78 ± 0.07 μg/mL) compared to rhizome extracts. Both extracts demonstrated high photoprotective potential (SPF = 42.3 and 39.3 for MKF and MKR, respectively) and substantial antiviral potency toward type 2 herpes simplex virus, with selectivity indices of 750-850 and no detectable cytotoxicity up to 2500 μg/mL. These results suggest that ultrasound-induced structural modifications enhance the bioactivity of P. oceanica polysaccharides, positioning them as multifunctional biomolecules with potential applications in pharmaceuticals, cosmeceuticals, and other industrial sectors. |
| title | Ultrasound-assisted valorization of Posidonia oceanica polysaccharides: Discovery of novel monosaccharides and enhanced multifunctional bioactivity. |
| topic | Polysaccharides Alismatales Monosaccharides Plant Leaves Antioxidants Antiviral Agents Humans Ultrasonic Waves Molecular Weight Herpesvirus 2, Human Rhizome |
| url | https://pubmed.ncbi.nlm.nih.gov/42140302/ |