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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Fish physiology and biochemistry
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42154098/ |
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Table of Contents:
- A lansoprazole-like structure derived from Streptomyces metabolites: evaluation of its protective effects on hepatorenal function, antioxidant activity, and immune parameters in African catfish challenged with Staphylococcus aureus. Abdelaziz, Rewan Almutairi, Saeedah M AbdelGawwad, Mohamed R Abass, Kasim Sakran Abdelaziz, Sheeren El-Demerdash, Azza SalahEldin Alotaibi, Riyadh Yassin, Mohamed Taha Animals Catfishes Staphylococcal Infections Staphylococcus aureus Antioxidants Lansoprazole Streptomyces Anti-Bacterial Agents Fish Diseases Liver Kidney Microbial Sensitivity Tests This study evaluated the antibacterial potential of a novel metabolite, a lansoprazole-like structure (LPZS), derived from the marine actinomycete Streptomyces huiliensis (PQ285591) against Staphylococcus aureus (MSSA). Out of 30 marine isolates from the Mediterranean Sea, S. huiliensis exhibited the most potent bioactivity. The purified metabolite, identified via NMR, TLC, HPLC, and GC-MS, demonstrated a significant minimum inhibitory concentration (MIC) of 0.5 μg/mL against S. aureus in vitro. The in vivo efficacy and safety were assessed using 120 African catfish (Clarias gariepinus) challenged with S. aureus (1.6 × 10⁶ CFU/mL). Treatment with LPZS (100 μg/mL) significantly (p