The Greenland shark genome: Insights into lifespan extremes and population dynamics.
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| Format: | Artículo científico |
| Language: | en |
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Proceedings of the National Academy of Sciences of the United States of America
2026
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| author | Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu |
| author_facet | Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu |
| collection | PubMed - marine biology |
| contents | The Greenland shark genome: Insights into lifespan extremes and population dynamics. Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu Animals Sharks Longevity Genome Population Dynamics Greenland The Greenland shark () is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gene family expansion and positive selection revealed classical longevity-related mechanisms, including immune enhancement, cancer resistance, and DNA repair, as well as additional features potentially associated with extended lifespan limits. Unique amino acid substitutions in the globular domain of linker histone H1.0 are predicted to enhance chromatin stability, and the species' distinctive gene repertoire provides a framework for generating hypotheses potentially linking ferroptosis to exceptional longevity. We also elucidate the dynamics of the effective population size () of the Greenland shark and its close relative, the Pacific sleeper shark (). These genomic analyses offer insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity. |
| format | Artículo científico |
| id | pubmed_42154556 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Proceedings of the National Academy of Sciences of the United States of America |
| record_format | pubmed |
| spellingShingle | The Greenland shark genome: Insights into lifespan extremes and population dynamics. Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu Animals Sharks Longevity Genome Population Dynamics Greenland The Greenland shark genome: Insights into lifespan extremes and population dynamics. Yang, Kaiqiao Nishiwaki, Kazuya Mizobata, Hideaki Liang, Jiancheng Asakawa, Shuichi Yoshitake, Kazutoshi Watanabe, Yuuki Y Hussey, Nigel E Kovacs, Kit M Lydersen, Christian Kadota, Mitsutaka Kuraku, Shigehiro Kinoshita, Shigeharu Animals Sharks Longevity Genome Population Dynamics Greenland The Greenland shark () is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gene family expansion and positive selection revealed classical longevity-related mechanisms, including immune enhancement, cancer resistance, and DNA repair, as well as additional features potentially associated with extended lifespan limits. Unique amino acid substitutions in the globular domain of linker histone H1.0 are predicted to enhance chromatin stability, and the species' distinctive gene repertoire provides a framework for generating hypotheses potentially linking ferroptosis to exceptional longevity. We also elucidate the dynamics of the effective population size () of the Greenland shark and its close relative, the Pacific sleeper shark (). These genomic analyses offer insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity. |
| title | The Greenland shark genome: Insights into lifespan extremes and population dynamics. |
| topic | Animals Sharks Longevity Genome Population Dynamics Greenland |
| url | https://pubmed.ncbi.nlm.nih.gov/42154556/ |