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Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.

Fuente: PubMed

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Bibliographic Details
Main Authors:	Bourg, Stéphane, Place, Matthieu, Copin, Chloé, Chaikuad, Apirat, Robert, Thomas, Holzmann, Hanna, Müller, Susanne, Bach, Stéphane, Ruchaud, Sandrine, Knapp, Stefan, Buron, Frédéric, Routier, Sylvain, Bonnet, Pascal
Format:	Artículo científico
Language:	en
Published:	European journal of medicinal chemistry 2026
Subjects:	Protein Serine-Threonine Kinases Humans Ligands Drug Design Protein Kinase Inhibitors Structure-Activity Relationship Protein-Tyrosine Kinases Molecular Structure Molecular Docking Simulation Crystallization Dose-Response Relationship, Drug Models, Molecular
Online Access:	Acceder al recurso
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