Biological-chemical method for synthesizing -menthane-3,8-diol.
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| Autori principali: | , , , , , |
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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Synthetic and systems biotechnology
2026
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| _version_ | 1868266044105162752 |
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| author | Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu |
| author_facet | Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu |
| collection | PubMed - marine biology |
| contents | Biological-chemical method for synthesizing -menthane-3,8-diol. Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu The cyclic monoterpene -menthane-3,8-diol exhibits highly effective mosquito-repellent activity. Current industrial production of PMD depends on chemically synthesized citronellal as a precursor. To provide a green, sustainable alternative for citronellal supply, we engineered a strain for efficient biosynthesis of citronellal. By enhancing geraniol synthesis, systematically redesigning the endogenous oxidoreductase system, and implementing metabolic optimization strategies, a citronellal titer of 0.13 g/L was achieved in shake-flask cultivation. By integrating this microbial fermentation step with subsequent chemical catalysis, we established a biological-chemical method for PMD production, achieving a final PMD yield of 0.64 g/L. This work represents the first semisynthetic route from glucose to PMD via a biological-chemical method, offering a novel and sustainable paradigm for PMD manufacture. |
| format | Artículo científico |
| id | pubmed_42182967 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Synthetic and systems biotechnology |
| record_format | pubmed |
| spellingShingle | Biological-chemical method for synthesizing -menthane-3,8-diol. Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu Biological-chemical method for synthesizing -menthane-3,8-diol. Zuo, Xiaoru Zhang, Huizhi Zhang, Zhanwei Ma, Yuanyuan Zhang, Chuanbo Lu, Wenyu The cyclic monoterpene -menthane-3,8-diol exhibits highly effective mosquito-repellent activity. Current industrial production of PMD depends on chemically synthesized citronellal as a precursor. To provide a green, sustainable alternative for citronellal supply, we engineered a strain for efficient biosynthesis of citronellal. By enhancing geraniol synthesis, systematically redesigning the endogenous oxidoreductase system, and implementing metabolic optimization strategies, a citronellal titer of 0.13 g/L was achieved in shake-flask cultivation. By integrating this microbial fermentation step with subsequent chemical catalysis, we established a biological-chemical method for PMD production, achieving a final PMD yield of 0.64 g/L. This work represents the first semisynthetic route from glucose to PMD via a biological-chemical method, offering a novel and sustainable paradigm for PMD manufacture. |
| title | Biological-chemical method for synthesizing -menthane-3,8-diol. |
| url | https://pubmed.ncbi.nlm.nih.gov/42182967/ |