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| Main Authors: | , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Marine life science & technology
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42186549/ |
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| _version_ | 1868266044098871296 |
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| author | Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li |
| author_facet | Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li |
| collection | PubMed - marine biology |
| contents | -variation--variation interactions between promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species. Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li Global warming may drive adaptive evolution by influencing natural selection and utilizing temperature-related phenotypic plasticity. However, predicting the evolutionary patterns of phenotypic plasticity under climate change remains a challenge, underscoring the need to elaborate on the underlying genetic and molecular mechanisms. In this study, we focus on the expression plasticity divergence of heat shock protein 90 (), which is temperature responsive and exhibits a strong selective sweep in the upstream noncoding region of two allopatric congeneric oyster species: cold-adapted and warm-adapted . Functional characterization confirmed expression as an ideal proxy for thermotolerance. The evolutionary divergence in constitutive and plastic expression patterns represents adaptation to the mean and variance in habitat temperature, respectively. By combining forward and reverse genetic approaches, four causative loci with G + G × E effects were identified in the promoter regions of . and . , indicating -variations. Moreover, the g.-2291G allele of the causative locus in is specifically bound to by the positive transcription factor purine-rich element binding protein B (PURB), explaining the constitutive expression of . Meanwhile, the response of to thermal stress determines the magnitude of plastic expression in . . This integrative study revealed that -variations interact with -variations and underlie the G × E effect under environmental changes, thereby mediating the divergence in plastic gene expression. Furthermore, we established a paradigm for studying genetic variants and their G × E impacts at a finer resolution, i.e., single-nucleotide level, in nonmodel organisms. The findings may deepen our understanding of the significant role of phenotypic plasticity in modulating adaptive responses and promote predictions of adaptive potential in marine organisms under climate change. The online version contains supplementary material available at 10.1007/s42995-026-00373-6. |
| format | Artículo científico |
| id | pubmed_42186549 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Marine life science & technology |
| record_format | pubmed |
| spellingShingle | -variation--variation interactions between promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species. Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li -variation--variation interactions between promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species. Jiang, Zhuxiang Wang, Chaogang Du, Mingyang Cong, Rihao Li, Ao Wang, Wei Zhang, Guofan Li, Li Global warming may drive adaptive evolution by influencing natural selection and utilizing temperature-related phenotypic plasticity. However, predicting the evolutionary patterns of phenotypic plasticity under climate change remains a challenge, underscoring the need to elaborate on the underlying genetic and molecular mechanisms. In this study, we focus on the expression plasticity divergence of heat shock protein 90 (), which is temperature responsive and exhibits a strong selective sweep in the upstream noncoding region of two allopatric congeneric oyster species: cold-adapted and warm-adapted . Functional characterization confirmed expression as an ideal proxy for thermotolerance. The evolutionary divergence in constitutive and plastic expression patterns represents adaptation to the mean and variance in habitat temperature, respectively. By combining forward and reverse genetic approaches, four causative loci with G + G × E effects were identified in the promoter regions of . and . , indicating -variations. Moreover, the g.-2291G allele of the causative locus in is specifically bound to by the positive transcription factor purine-rich element binding protein B (PURB), explaining the constitutive expression of . Meanwhile, the response of to thermal stress determines the magnitude of plastic expression in . . This integrative study revealed that -variations interact with -variations and underlie the G × E effect under environmental changes, thereby mediating the divergence in plastic gene expression. Furthermore, we established a paradigm for studying genetic variants and their G × E impacts at a finer resolution, i.e., single-nucleotide level, in nonmodel organisms. The findings may deepen our understanding of the significant role of phenotypic plasticity in modulating adaptive responses and promote predictions of adaptive potential in marine organisms under climate change. The online version contains supplementary material available at 10.1007/s42995-026-00373-6. |
| title | -variation--variation interactions between promoters shape G × E effects and underlie divergent phenotypic thermal adaptation plasticity in two congeneric oyster species. |
| url | https://pubmed.ncbi.nlm.nih.gov/42186549/ |