Cover Image

The Evolution of IL6-IL6R-JAK-STAT Signaling Pathway in Metazoan.

Fuente: PubMed

Saved in:

Bibliographic Details
Main Authors:	Yu, Hong, Chang, Renle, Wang, Houyou, He, Muchun, Sun, Jiejie, Song, Linsheng
Format:	Artículo científico
Language:	en
Published:	Biology 2026
Online Access:	Acceder al recurso
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Tocilizumab Mitigates Immune Checkpoint Inhibitor–Induced Colitis and Inhibits Tumor Growth by Targeting the IL‐6‐JAK2‐STAT3 Signaling Pathway
by: Yanxin Chen, et al.
Published: (2026)

SGK1 Inhibition Improved Mitochondrial Dysfunction and Astrocyte Senescence in Hepatic Encephalopathy via IL ‐6/ JAK2 / STAT3 Signaling Pathway
by: Guqing Luo, et al.
Published: (2025)

Lactobacillus reuteri Alleviates Hyperoxia‐Induced BPD by Activating IL‐22/STAT3 Signaling Pathway in Neonatal Mice
by: Meiyu Zhang, et al.
Published: (2024)

miR‐224‐5p Suppresses Non‐Small Cell Lung Cancer via IL6ST‐Mediated Regulation of the JAK2/STAT3 Pathway
by: Jiao Tian, et al.
Published: (2025)

DHCR7 drives AML development through the IL6 / JAK2 / STAT3 signalling pathway
by: Xu Dai, et al.
Published: (2026)

Investigating the association between the tissue expression of miRNA‐101, JAK2/STAT3 with TNF‐α, IL‐6, IL‐1β, and IL‐10 cytokines in the ulcerative colitis patients
by: Qazaleh Voshagh, et al.
Published: (2024)

Sappanone A Exerted Strong Anti‐Inflammatory Effects in the Treatment of Atopic Dermatitis Through IL‐21R ‐Mediated JAK1 / STAT3 Pathway
by: Jiayi Li, et al.
Published: (2025)

IL6/IL10/TLR4 Govern Immunogenic Cell Death in Aortic Dissection
by: Yukui Du, et al.
Published: (2026)

IL‐4‐JAK1‐STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression
by: Sihui Cao, et al.
Published: (2025)

Involvement of IL‐6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate
by: Gaber F. Ali, et al.
Published: (2025)

Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis
by: Xiang Zhao, et al.
Published: (2025)

Angiotensin II Receptor‐Associated Protein ( AGTRAP ) Enhances Glioma Cell Survival Through the IL ‐6/ JAK2 / STAT3 Pathway and Correlates With an Immunosuppressive Microenvironment
by: Siyu Chen, et al.
Published: (2026)

IL‐27: A Double‐Edged Sword in Immune Regulation via JAK‐STAT Orchestration
by: Xiangqi Zhang, et al.
Published: (2026)

Filgotinib Improves Experimental Pulmonary Fibrosis by Modulating JAK1/STAT3/SOCS3/IL‐17A Signalling
by: Yunying Lv, et al.
Published: (2025)

Linagliptin Mitigates DMH‐Induced Colorectal Cancer in Rats: Crosstalk Between NFAT and IL‐6/JAK2/STAT3/NF‐κB Signaling Hubs
by: Mohamed O. Mahmoud, et al.
Published: (2025)

Correction to “miR‐223 Improves Intestinal Inflammation Through Inhibiting the IL‐6/STAT3 Signaling Pathway in Dextran Sodium Sulfate‐Induced Experimental Colitis”
Published: (2025)

Beryllium Sulfate–Induced Cellular Senescence via the IL‐6/STAT3 Pathway to Promote Pulmonary Fibrosis
by: Yanping Lu, et al.
Published: (2026)

TYK2 and IL‐23 Pathway Therapies in Psoriasis: Associations With IL‐6, Tryptophan Metabolism, and Depressive Symptoms
by: Lanmei Lin, et al.
Published: (2026)

Microalgae-Based Fucoxanthin Attenuates Rheumatoid Arthritis by Targeting the JAK-STAT Signaling Pathway and Gut Microbiota.
by: Xu, Hui-Ying, et al.
Published: (2025)

IL‐6 and Olfactory Dysfunction: Focus on Changes, Effects, and Mechanisms
by: Xiao-Yu Song, et al.
Published: (2025)

Ropivacaine synergizes with sorafenib to induce apoptosis of hepatocellular carcinoma cells via the IL‐6/STAT3 pathway
by: Wenting Wang, et al.
Published: (2024)

ACSM3 Suppresses Ovarian Cancer Progression by Inactivating the IFN‐γ/JAK/STAT3 Signaling Pathway
by: Juan Wang, et al.
Published: (2025)

Inhibition of IL‐6/STAT3 Signaling by N‐Trans‐Hibiscusamide and Its Derivative in a Mouse Model of Collagen‐Induced Arthritis
by: Hyung Jin Lim, et al.
Published: (2026)

Inhibition of IL‐21/IL‐21R Signaling by Fucoxanthin: Structure‐Based and Experimental Analysis
by: Pinglang Ruan, et al.
Published: (2025)

JPH3 Facilitates Cisplatin Resistance in Anaplastic Thyroid Cancer via Activation of the JAK – STAT Signaling Pathway
by: Xiuyan Wang, et al.
Published: (2026)

PD-L1, STAT3, IL6, and EGFR Immunoexpressions in High-Grade Osteosarcoma
by: Nayla Rahmadiani, et al.
Published: (2024)

UBE2T mediates SORBS3 ubiquitination to enhance IL‐6/STAT3 signaling and promote lung adenocarcinoma progression
by: Jiangtao Pu, et al.
Published: (2024)

Erratum to “The Role of Natural Products as Inhibitors of JAK/STAT Signaling Pathways in Glioblastoma Treatment”
Published: (2025)

Alleviating Effects of Citrus Polymethoxyflavones on Autoimmune Thyroiditis via IL‐17 Signaling Pathway
by: Manxi Wu, et al.
Published: (2025)

Verteporfin Mitigates Isoproterenol‐Induced Myocardial Hypertrophy by Attenuating IL‐6/STAT3 in Cardiac Fibroblasts
by: Sunpeng Sheng, et al.
Published: (2025)

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3 Tyr705 Pathway
by: JeongMin Sim, et al.
Published: (2026)

Th17/IL‐17A Drives Alveolar Bone Loss via the JAK/STAT3‐RANKL Axis in the Periodontal Ligament
by: Die Lv, et al.
Published: (2025)

C‐Section After IL‐6 Exposure Triggers Brain Inflammation in Neonates Similar to That of Natural Delivery With or Without IL‐6 Exposure
by: Wangli Tian, et al.
Published: (2026)

STAT6 tunes maximum T cell IL‐4 production from stochastically regulated Il4 alleles
by: Ryan L Kyle, et al.
Published: (2024)

Activated Peripheral CD8 + T Lymphocytes Inhibit the Proliferation of Hippocampal Neural Stem Cells via the IFN‐γ/JAK/STAT Signaling Pathway
by: Xiaowei Li, et al.
Published: (2025)

The Role of CXCL13 in GC‐1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Through JAK2/STAT3 Signaling Pathway
by: Yuzhu Lei, et al.
Published: (2025)

The binding of PKCε and MEG2 to STAT3 regulates IL ‐6‐mediated microglial hyperalgesia during inflammatory pain
by: Xiongjuan Li, et al.
Published: (2024)

The “Heater” of “Cold” Tumors–Blocking IL‐6
by: Weigao Pu, et al.
Published: (2024)

Association of Cytokine IL-17, IL-4, IL-6, and IL-12 Gene Polymorphisms in Rheumatoid Arthritis Patients in a Tertiary Care Hospital in Bangladesh
by: Taskin Jahan, et al.
Published: (2024)

Water intake regulates mucosal immunity in rat jejunal villi via IL ‐1β, IL ‐6, and IL ‐10
by: Norika Kuneshita, et al.
Published: (2026)