Identification, Screening and Mechanism Analysis of Anti-Parkinson's Disease Peptides from Protein Hydrolysates.
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| Natura: | Artículo científico |
| Lingua: | en |
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Marine drugs
2026
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| _version_ | 1868266044091531265 |
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| author | Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan |
| author_facet | Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan |
| collection | PubMed - marine biology |
| contents | Identification, Screening and Mechanism Analysis of Anti-Parkinson's Disease Peptides from Protein Hydrolysates. Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan Animals Zebrafish Neuroprotective Agents Peptides Protein Hydrolysates Molecular Docking Simulation Oxidative Stress Parkinson Disease Antiparkinson Agents Disease Models, Animal Dopaminergic Neurons Bioactive Peptides, Dietary Humans Snails At present, there is still a lack of effective treatments to slow the progression of Parkinson's disease. Naturally derived active substances, valued for their safety and multi-target potential, have become an important direction in anti-PD drug development, with marine organisms representing a valuable source of bioactive peptides. This study aimed to isolate and identify anti-PD peptides from protein hydrolysates. Through bioactivity-guided screening combined with an MPTP-induced zebrafish PD model, three novel active peptides-KSTELLI, FLVKLPMFM, and SDSLSEILIS-were successfully identified. The study showed that these peptides significantly alleviated dopaminergic neuron loss, improved the cerebral vascular system, restored motor and sensory function, and alleviated oxidative stress. Molecular docking confirmed their stable binding to key PD targets (DDC, α-synuclein, and MAO-B). Further transcriptomic and gene expression analyses revealed that their neuroprotective effects involve the regulation of pathways related to metabolism, oxidative stress, inflammation, and apoptosis, with the three peptides exhibiting distinct mechanistic emphases. The research demonstrates that these marine-derived peptides exert neuroprotective effects through a synergistic multi-target mechanism, laying a foundation for the development of novel lead compounds against Parkinson's disease. |
| format | Artículo científico |
| id | pubmed_42188315 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Marine drugs |
| record_format | pubmed |
| spellingShingle | Identification, Screening and Mechanism Analysis of Anti-Parkinson's Disease Peptides from Protein Hydrolysates. Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan Animals Zebrafish Neuroprotective Agents Peptides Protein Hydrolysates Molecular Docking Simulation Oxidative Stress Parkinson Disease Antiparkinson Agents Disease Models, Animal Dopaminergic Neurons Bioactive Peptides, Dietary Humans Snails Identification, Screening and Mechanism Analysis of Anti-Parkinson's Disease Peptides from Protein Hydrolysates. Wang, Qingzhong Shao, Shuqin Wang, Yizhuo Fan, Wenshuai Wang, Zilong Liu, Xuchang Liu, Kechun Zhang, Shanshan Animals Zebrafish Neuroprotective Agents Peptides Protein Hydrolysates Molecular Docking Simulation Oxidative Stress Parkinson Disease Antiparkinson Agents Disease Models, Animal Dopaminergic Neurons Bioactive Peptides, Dietary Humans Snails At present, there is still a lack of effective treatments to slow the progression of Parkinson's disease. Naturally derived active substances, valued for their safety and multi-target potential, have become an important direction in anti-PD drug development, with marine organisms representing a valuable source of bioactive peptides. This study aimed to isolate and identify anti-PD peptides from protein hydrolysates. Through bioactivity-guided screening combined with an MPTP-induced zebrafish PD model, three novel active peptides-KSTELLI, FLVKLPMFM, and SDSLSEILIS-were successfully identified. The study showed that these peptides significantly alleviated dopaminergic neuron loss, improved the cerebral vascular system, restored motor and sensory function, and alleviated oxidative stress. Molecular docking confirmed their stable binding to key PD targets (DDC, α-synuclein, and MAO-B). Further transcriptomic and gene expression analyses revealed that their neuroprotective effects involve the regulation of pathways related to metabolism, oxidative stress, inflammation, and apoptosis, with the three peptides exhibiting distinct mechanistic emphases. The research demonstrates that these marine-derived peptides exert neuroprotective effects through a synergistic multi-target mechanism, laying a foundation for the development of novel lead compounds against Parkinson's disease. |
| title | Identification, Screening and Mechanism Analysis of Anti-Parkinson's Disease Peptides from Protein Hydrolysates. |
| topic | Animals Zebrafish Neuroprotective Agents Peptides Protein Hydrolysates Molecular Docking Simulation Oxidative Stress Parkinson Disease Antiparkinson Agents Disease Models, Animal Dopaminergic Neurons Bioactive Peptides, Dietary Humans Snails |
| url | https://pubmed.ncbi.nlm.nih.gov/42188315/ |