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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Nature reviews. Microbiology
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42215729/ |
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| _version_ | 1868266041754255360 |
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| author | Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo |
| author_facet | Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo |
| collection | PubMed - marine biology |
| contents | Infection cycles of viruses of the phylum Nucleocytoviricota. Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo The phylum Nucleocytoviricota, formerly known as nucleocytoplasmic large DNA viruses (NCLDVs), comprises evolutionarily related viruses with remarkably diverse genome sizes, coding capacities and virion morphologies. These viruses infect hosts across the eukaryotic tree of life, from protists to humans, and are believed to have emerged during the early stages of eukaryotic evolution. How the basic aspects of virus-host interaction have evolved in different lineages and whether they share a conserved infection cycle remain unclear. In this Review, we synthesize the information on the infection cycles of model representatives from the major orders within the phylum, revealing both shared traits and lineage-specific innovations. We compare the information available for the extensively studied poxviruses, asfiviruses, iridoviruses and chloroviruses with insights from the rapidly expanding literature on the mimiviruses, pandoraviruses, marseilleviruses and pithoviruses. We provide an overview of the molecular details underlying the key stages of Nucleocytoviricota infection cycles: entry via membrane fusion, formation of viral factories organized via phase separation, genome replication, virion morphogenesis through a crescent intermediate, and egress. We highlight outstanding questions in the field, unify concepts across traditionally separated research areas, and provide a conceptual framework to guide future cell biology studies on large double-stranded DNA viruses. |
| format | Artículo científico |
| id | pubmed_42215729 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature reviews. Microbiology |
| record_format | pubmed |
| spellingShingle | Infection cycles of viruses of the phylum Nucleocytoviricota. Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo Infection cycles of viruses of the phylum Nucleocytoviricota. Abergel, Chantal Abrahão, Jônatas Santos Coulibaly, Fasseli Fischer, Matthias Jeudy, Sandra Knorr, Roland L Krupovic, Mart Legendre, Matthieu Pérez-Núñez, Daniel Nwokolo, Chisom Queiroz, Victória Schmitt, Alain Van Etten, James L Willemsen, Anouk Bisio, Hugo The phylum Nucleocytoviricota, formerly known as nucleocytoplasmic large DNA viruses (NCLDVs), comprises evolutionarily related viruses with remarkably diverse genome sizes, coding capacities and virion morphologies. These viruses infect hosts across the eukaryotic tree of life, from protists to humans, and are believed to have emerged during the early stages of eukaryotic evolution. How the basic aspects of virus-host interaction have evolved in different lineages and whether they share a conserved infection cycle remain unclear. In this Review, we synthesize the information on the infection cycles of model representatives from the major orders within the phylum, revealing both shared traits and lineage-specific innovations. We compare the information available for the extensively studied poxviruses, asfiviruses, iridoviruses and chloroviruses with insights from the rapidly expanding literature on the mimiviruses, pandoraviruses, marseilleviruses and pithoviruses. We provide an overview of the molecular details underlying the key stages of Nucleocytoviricota infection cycles: entry via membrane fusion, formation of viral factories organized via phase separation, genome replication, virion morphogenesis through a crescent intermediate, and egress. We highlight outstanding questions in the field, unify concepts across traditionally separated research areas, and provide a conceptual framework to guide future cell biology studies on large double-stranded DNA viruses. |
| title | Infection cycles of viruses of the phylum Nucleocytoviricota. |
| url | https://pubmed.ncbi.nlm.nih.gov/42215729/ |