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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
The Journal of organic chemistry
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42223449/ |
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| _version_ | 1868266041743769601 |
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| author | Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung |
| author_facet | Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung |
| collection | PubMed - marine biology |
| contents | Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral . Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Two pairs of enantiomeric diterpenoids, (±)-sclerofish A () and (±)-sclerofish B (), featuring a rare 4/7/6-fused tricyclic framework, were isolated from the soft coral by molecular networking-guided isolation. Their structures were elucidated by comprehensive spectroscopic analyses, including NMR, HRESIMS, TDDFT-ECD, and DP4+ analysis. A plausible biogenetic pathway, originating from geranylgeranyl pyrophosphate (GGPP) was proposed to rationalize the formation of the unusual bicyclo[4.3.1]decane subunit and the resulting 4/7/6-fused skeleton. Compound exhibited inhibition of Huh-7 cells with IC values of 5.1 ± 0.9 and 4.9 ± 0.3 μM, respectively, and showed selective cytotoxicity toward cancer cells (SI > 9.7), whereas compound displayed comparatively weaker activity. These findings expand the structural diversity of xeniaphyllane-type diterpenoids and highlight the soft coral as a valuable source of structurally unique and biologically relevant marine natural products. |
| format | Artículo científico |
| id | pubmed_42223449 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | The Journal of organic chemistry |
| record_format | pubmed |
| spellingShingle | Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral . Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral . Luu, Phuong Vu Phan, Thuy-Tien Thi Huynh, Quoc-Dung Tran Pham, Ngoc-Thac Le, Huong-Giang Chen, Lo-Yun Ton-Nu, Huong Lien Nguyen, Cuong-Quoc Shen, Yao-An Fan, Yu-Jui Su, Jui-Hsin Peng, Bo-Rong Lai, Kuei-Hung Two pairs of enantiomeric diterpenoids, (±)-sclerofish A () and (±)-sclerofish B (), featuring a rare 4/7/6-fused tricyclic framework, were isolated from the soft coral by molecular networking-guided isolation. Their structures were elucidated by comprehensive spectroscopic analyses, including NMR, HRESIMS, TDDFT-ECD, and DP4+ analysis. A plausible biogenetic pathway, originating from geranylgeranyl pyrophosphate (GGPP) was proposed to rationalize the formation of the unusual bicyclo[4.3.1]decane subunit and the resulting 4/7/6-fused skeleton. Compound exhibited inhibition of Huh-7 cells with IC values of 5.1 ± 0.9 and 4.9 ± 0.3 μM, respectively, and showed selective cytotoxicity toward cancer cells (SI > 9.7), whereas compound displayed comparatively weaker activity. These findings expand the structural diversity of xeniaphyllane-type diterpenoids and highlight the soft coral as a valuable source of structurally unique and biologically relevant marine natural products. |
| title | Sclerofish A and B: Two Pairs of Enantiomeric Diterpenoids Featuring a 4/7/6-Fused Tricyclic Scaffold from the Soft Coral . |
| url | https://pubmed.ncbi.nlm.nih.gov/42223449/ |