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| Auteurs principaux: | , , , , |
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| Format: | Artículo científico |
| Langue: | en |
| Publié: |
Critical reviews in food science and nutrition
2026
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| Accès en ligne: | https://pubmed.ncbi.nlm.nih.gov/42228631/ |
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| _version_ | 1868266041738526720 |
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| author | Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi |
| author_facet | Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi |
| collection | PubMed - marine biology |
| contents | Cross-kingdom signals: microbial, metabolites, and immune cells on the gut-breast axis. Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi The mammary gland is a dynamic mucosal organ whose structure and function are continually reshaped across pregnancy, lactation, and involution. Emerging evidence places it within a broader gut-breast axis in which intestinal microbes and their products influence mammary immunity, epithelial programs, and the composition of human milk. Three mechanistic lanes organize this crosstalk. First, microbial signals-ranging from structural ligands to extracellular vesicles-can reach the breast and tune innate sensing. Second, gut-derived metabolites-notably short-chain fatty acids (SCFA), secondary bile acids, and tryptophan catabolites-circulate to the gland and act on host receptors to regulate barrier integrity, inflammation, and tumor biology. Third, gut-imprinted immune cells traffic to the lactating breast, exporting protective secretory immunoglobulin A into milk. These routes have tangible clinical implications: selective probiotics reduce mastitis risk and aid abscess recovery; SCFA- and bile-acid-linked pathways protect mammary barriers; and specific commensals or pathobionts can shape breast cancer progression and therapy response. Because milk and mammary tissue are low-biomass niches, rigorous contamination controls are essential for reproducibility. This review synthesizes cross-kingdom signals in the gut-breast axis and outlines translational opportunities-from dietary fiber and targeted postbiotics to bile-acid pathway modulation and antibiotic stewardship-to improve lactation health and inform oncology. |
| format | Artículo científico |
| id | pubmed_42228631 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Critical reviews in food science and nutrition |
| record_format | pubmed |
| spellingShingle | Cross-kingdom signals: microbial, metabolites, and immune cells on the gut-breast axis. Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi Cross-kingdom signals: microbial, metabolites, and immune cells on the gut-breast axis. Cheong, Kit-Leong Li, Jiajing Wang, Min Wang, Dongju Zhong, Saiyi The mammary gland is a dynamic mucosal organ whose structure and function are continually reshaped across pregnancy, lactation, and involution. Emerging evidence places it within a broader gut-breast axis in which intestinal microbes and their products influence mammary immunity, epithelial programs, and the composition of human milk. Three mechanistic lanes organize this crosstalk. First, microbial signals-ranging from structural ligands to extracellular vesicles-can reach the breast and tune innate sensing. Second, gut-derived metabolites-notably short-chain fatty acids (SCFA), secondary bile acids, and tryptophan catabolites-circulate to the gland and act on host receptors to regulate barrier integrity, inflammation, and tumor biology. Third, gut-imprinted immune cells traffic to the lactating breast, exporting protective secretory immunoglobulin A into milk. These routes have tangible clinical implications: selective probiotics reduce mastitis risk and aid abscess recovery; SCFA- and bile-acid-linked pathways protect mammary barriers; and specific commensals or pathobionts can shape breast cancer progression and therapy response. Because milk and mammary tissue are low-biomass niches, rigorous contamination controls are essential for reproducibility. This review synthesizes cross-kingdom signals in the gut-breast axis and outlines translational opportunities-from dietary fiber and targeted postbiotics to bile-acid pathway modulation and antibiotic stewardship-to improve lactation health and inform oncology. |
| title | Cross-kingdom signals: microbial, metabolites, and immune cells on the gut-breast axis. |
| url | https://pubmed.ncbi.nlm.nih.gov/42228631/ |