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| Main Authors: | , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Organic letters
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42234138/ |
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Table of Contents:
- Genome-Driven Discovery of Neuraminidase-Inhibiting and Antibacterial Chermsinols A and B: Orsellinic-Acid-Derived Steroid and Meroterpenoid from Marine-Sourced . Hu, Xue-Yi Li, Xiao-Ming Liu, Hui Wang, Bin-Gui Meng, Ling-Hong Penicillium Anti-Bacterial Agents Steroids Molecular Structure Terpenes Neuraminidase Microbial Sensitivity Tests Resorcinols Two orsellinic acid (OA)-derived metabolites, chermsinols A and B ( and ), were isolated from the marine red alga-derived endophytic EN-480 based on its genomic analysis. Compound is a steroid featuring an unprecedented 6/6/6/5/6/6 ring system, likely formed from a Diels-Alder reaction, while compound is a meroterpenoid containing a unique ring-opened ketone chain derived from 3,5-dimethylorsellinic acid (DMOA) and possessing a continuous spiro system. Results from bioassays revealed that compound exhibits inhibitory activity against influenza neuraminidase as well as antibacterial properties. The plausible biosynthetic pathways for and were proposed on the basis of the genomic data analysis of the producing fungus.