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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Science advances
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42234737/ |
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| _version_ | 1868266041728040960 |
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| author | Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua |
| author_facet | Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua |
| collection | PubMed - marine biology |
| contents | Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids. Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua Animals Female DNA Transposable Elements Male Sex Determination Processes Evolution, Molecular Cichlids Sex Differentiation Phylogeny Promoter Regions, Genetic Sex-determination mechanisms and their master regulators are diverse among vertebrates. Components of downstream regulatory pathways can sometimes be co-opted as new upstream triggers. Here, we report a notable finding of cross-pathway recruitment: A gene from the female differentiation cascade was repurposed as a male master sex-determining (MSD) gene. We identify , a Y-linked truncated duplicate of the female-associated , as the MSD gene in Mozambique tilapia. originated through duplication and translocation in an ancestral cichlid lineage and subsequently introgressed into multiple lineages. Transposable elements facilitated 's emergence by mediating duplication, truncation, and regulatory rewiring. Functionally, FIGLAY suppresses the promoter activated by the FIGLA/E12 heterodimer, acting as a dominant-negative regulator that inhibits ovarian differentiation and promotes testis development. This discovery reveals an unprecedented evolutionary route from female to male sex determination, i.e., a "genetic defection" from an initially female pathway. This previously unknown mechanism expands the vertebrate sex-determination toolkit. |
| format | Artículo científico |
| id | pubmed_42234737 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Science advances |
| record_format | pubmed |
| spellingShingle | Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids. Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua Animals Female DNA Transposable Elements Male Sex Determination Processes Evolution, Molecular Cichlids Sex Differentiation Phylogeny Promoter Regions, Genetic Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids. Wang, Le Sun, Fei Yang, Zituo Lee, May Wong, Joey Yeo, Shadame Wen, Yanfei Meyer, Axel Piferrer, Francesc Schartl, Manfred Yue, Gen Hua Animals Female DNA Transposable Elements Male Sex Determination Processes Evolution, Molecular Cichlids Sex Differentiation Phylogeny Promoter Regions, Genetic Sex-determination mechanisms and their master regulators are diverse among vertebrates. Components of downstream regulatory pathways can sometimes be co-opted as new upstream triggers. Here, we report a notable finding of cross-pathway recruitment: A gene from the female differentiation cascade was repurposed as a male master sex-determining (MSD) gene. We identify , a Y-linked truncated duplicate of the female-associated , as the MSD gene in Mozambique tilapia. originated through duplication and translocation in an ancestral cichlid lineage and subsequently introgressed into multiple lineages. Transposable elements facilitated 's emergence by mediating duplication, truncation, and regulatory rewiring. Functionally, FIGLAY suppresses the promoter activated by the FIGLA/E12 heterodimer, acting as a dominant-negative regulator that inhibits ovarian differentiation and promotes testis development. This discovery reveals an unprecedented evolutionary route from female to male sex determination, i.e., a "genetic defection" from an initially female pathway. This previously unknown mechanism expands the vertebrate sex-determination toolkit. |
| title | Transposons drove the evolution of a male sex-determining gene from a female gene with deep introgression across cichlids. |
| topic | Animals Female DNA Transposable Elements Male Sex Determination Processes Evolution, Molecular Cichlids Sex Differentiation Phylogeny Promoter Regions, Genetic |
| url | https://pubmed.ncbi.nlm.nih.gov/42234737/ |