Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation.
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| Format: | Artículo científico |
| Sprache: | en |
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Cell
2026
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| author | Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua |
| author_facet | Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua |
| collection | PubMed - marine biology |
| contents | Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation. Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua The deep-sea supergiant isopod is renowned for surviving over 5 years without food, which is a crucial adaptive trait for megafauna inhabiting extreme environments. Here, morphological, physiological, and genomic comparisons of deep-sea isopods reveal a dual adaptive strategy underlying this trait: a distended, food-retentive stomach that enables episodic hyperphagia and a markedly reduced basal metabolic rate (BMR). Notably, central to this adaptation is the ancient horizontal acquisition of the microbial energy metabolism-related gene ND1, which thereafter achieved significant dosage enhancement via post-transfer duplication and ultra-high expression that is specifically regulated by histone acetylation at its promoter. Functional assays in transgenic zebrafish, nematodes, and cell lines demonstrate that ND1 reduces BMR by downregulating endogenous energy-production genes and thus extends starvation survival under cold-induced metabolic suppression. These findings uncover an exceptional evolutionary strategy whereby deep-sea megafauna co-opts and epigenetically optimizes exogenous microbial genes to reconcile the metabolic conflict between energy-demanding gigantism and extreme energy limitation. |
| format | Artículo científico |
| id | pubmed_42248139 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Cell |
| record_format | pubmed |
| spellingShingle | Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation. Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation. Yuan, Jianbo Zhang, Xiaojun Li, Shihao Wang, Kun Sun, Yamin Luo, Man Su, Yang Kou, Qi Liu, Chengzhang Yu, Yang Li, Roujing Wang, Long Li, Xinzheng Chu, Kahou Xiang, Jianhai Li, Fuhua The deep-sea supergiant isopod is renowned for surviving over 5 years without food, which is a crucial adaptive trait for megafauna inhabiting extreme environments. Here, morphological, physiological, and genomic comparisons of deep-sea isopods reveal a dual adaptive strategy underlying this trait: a distended, food-retentive stomach that enables episodic hyperphagia and a markedly reduced basal metabolic rate (BMR). Notably, central to this adaptation is the ancient horizontal acquisition of the microbial energy metabolism-related gene ND1, which thereafter achieved significant dosage enhancement via post-transfer duplication and ultra-high expression that is specifically regulated by histone acetylation at its promoter. Functional assays in transgenic zebrafish, nematodes, and cell lines demonstrate that ND1 reduces BMR by downregulating endogenous energy-production genes and thus extends starvation survival under cold-induced metabolic suppression. These findings uncover an exceptional evolutionary strategy whereby deep-sea megafauna co-opts and epigenetically optimizes exogenous microbial genes to reconcile the metabolic conflict between energy-demanding gigantism and extreme energy limitation. |
| title | Deep-sea megafauna co-opts microbial energy metabolism genes to withstand ultra-long starvation. |
| url | https://pubmed.ncbi.nlm.nih.gov/42248139/ |