Rewiring mTOR signaling in Alzheimer's disease: emerging mTOR modulators beyond oncology.
Fuente:
PubMed
Salvato in:
| Autori principali: | Lohnes, Benedikt Jakob, Myskova, Aneta, Tyagi, Arti, Hartwig, Udo Frank, Poddar, Nitesh Kumar |
|---|---|
| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Bioscience reports
2026
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
Documenti analoghi
Computational Analysis of Azole Derivatives Targeting the PI3K/AKT/mTOR Pathway With In Vitro Cytotoxicity and Autophagy Evaluation.
di: Regurajan, Rathika, et al.
Pubblicazione: (2026)
di: Regurajan, Rathika, et al.
Pubblicazione: (2026)
DHA affects ISKNV-induced autophagy flux via the AMPK/mTOR/ULK1 and BECN1/SQSTM1 axes, limiting viral replication in fish cells.
di: Chen, Kuang-Wen, et al.
Pubblicazione: (2026)
di: Chen, Kuang-Wen, et al.
Pubblicazione: (2026)
Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.
di: Zhang, Xinyu, et al.
Pubblicazione: (2025)
di: Zhang, Xinyu, et al.
Pubblicazione: (2025)
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.
di: Xie, Zhangdan, et al.
Pubblicazione: (2025)
di: Xie, Zhangdan, et al.
Pubblicazione: (2025)
Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in .
di: Tahan Zadeh, Navid, et al.
Pubblicazione: (2025)
di: Tahan Zadeh, Navid, et al.
Pubblicazione: (2025)
Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations.
di: Yasir, Muhammad, et al.
Pubblicazione: (2024)
di: Yasir, Muhammad, et al.
Pubblicazione: (2024)
In vitro cytotoxic and pro-apoptotic effects of Chaetoceros socialis ethanolic extract on prostate (LNCap) and glioblastoma (U-87 MG) cells via modulation of AKT/PTEN, mTOR, BAX/BCL2, and Caspase pathways.
di: Asoudeh-Fard, Abbas, et al.
Pubblicazione: (2025)
di: Asoudeh-Fard, Abbas, et al.
Pubblicazione: (2025)
Primary Cilia-Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress-Induced Life or Death Decisions.
di: Xu, Jia, et al.
Pubblicazione: (2025)
di: Xu, Jia, et al.
Pubblicazione: (2025)
Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships.
di: Bourg, Stéphane, et al.
Pubblicazione: (2026)
di: Bourg, Stéphane, et al.
Pubblicazione: (2026)
BIK1 and ATL31/6 are essential for fucoidan hydrolysate-triggered stomatal closure in Arabidopsis.
di: Chen, Kexin, et al.
Pubblicazione: (2025)
di: Chen, Kexin, et al.
Pubblicazione: (2025)
Activation of prep expression by Tet2 promotes the proliferation of bipotential progenitor cells during liver regeneration.
di: Jia, Kun, et al.
Pubblicazione: (2025)
di: Jia, Kun, et al.
Pubblicazione: (2025)
The novel marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol exhibits anticancer activity by regulating multiple signaling pathways in human glioblastoma cells: Blocking EGF signaling.
di: Yamaguchi, Masayoshi, et al.
Pubblicazione: (2025)
di: Yamaguchi, Masayoshi, et al.
Pubblicazione: (2025)
Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors.
di: Du, Lin, et al.
Pubblicazione: (2025)
di: Du, Lin, et al.
Pubblicazione: (2025)
Synthesis and biological activity of 1H-pyrrolo[3,2-g]isoquinolines as Haspin kinase inhibitors.
di: Malosse, Killian, et al.
Pubblicazione: (2025)
di: Malosse, Killian, et al.
Pubblicazione: (2025)
Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
di: Wicaksono, Danar, et al.
Pubblicazione: (2024)
di: Wicaksono, Danar, et al.
Pubblicazione: (2024)
Phosphoethanolamine cytidylyltransferase 2 integrates DAG metabolism and TBK1 activation to regulate antiviral innate immunity.
di: Lai, Wencong, et al.
Pubblicazione: (2026)
di: Lai, Wencong, et al.
Pubblicazione: (2026)
Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice.
di: Chang, Yun-Ching, et al.
Pubblicazione: (2025)
di: Chang, Yun-Ching, et al.
Pubblicazione: (2025)
Evolutionary analysis and immune-induced expression and mA modification of RIPK1 and RIPK2 in the miiuy croaker.
di: Xing, Qianru, et al.
Pubblicazione: (2025)
di: Xing, Qianru, et al.
Pubblicazione: (2025)
A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.
di: Wisessaowapak, Churaibhon, et al.
Pubblicazione: (2026)
di: Wisessaowapak, Churaibhon, et al.
Pubblicazione: (2026)
Diphenyl Disulfide Exerts Dual Cytotoxic Effects by Inducing Ferroptosis and Apoptosis in Melanoma Cells.
di: Chen, Sheng-Yuan, et al.
Pubblicazione: (2026)
di: Chen, Sheng-Yuan, et al.
Pubblicazione: (2026)
Oligonol, an Oligomerized Polyphenol from , Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia.
di: Chang, Yun-Ching, et al.
Pubblicazione: (2024)
di: Chang, Yun-Ching, et al.
Pubblicazione: (2024)
SVCV phosphoprotein hijacks phase separation to immobilize the IRF3-TBK1 signaling axis and suppress interferon antiviral immunity.
di: Wang, Yueyi, et al.
Pubblicazione: (2026)
di: Wang, Yueyi, et al.
Pubblicazione: (2026)
Comparison of effects of m-TOR inhibitors and calcineurin inhibitor on SUPAR and ox-LDL levels in renal transplant recipients
di: Banu Yılmaz
Pubblicazione: (2022)
di: Banu Yılmaz
Pubblicazione: (2022)
Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.
di: Wang, Chaogang, et al.
Pubblicazione: (2024)
di: Wang, Chaogang, et al.
Pubblicazione: (2024)
Grass carp reovirus VP6 inhibits IFN production by degrading TBK1 through the autophagy pathway.
di: Xu, Xiao, et al.
Pubblicazione: (2025)
di: Xu, Xiao, et al.
Pubblicazione: (2025)
Data-Independent Acquisition-Based Quantitative Proteomics, Nontargeted Metabolomics, and Protein-Ligand Interaction Reveal the Mechanism of Baicalin Inhibiting βhemolytic/cytolytic Activities of .
di: Li, Guihua, et al.
Pubblicazione: (2026)
di: Li, Guihua, et al.
Pubblicazione: (2026)
Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.
di: Lu, Long-Feng, et al.
Pubblicazione: (2026)
di: Lu, Long-Feng, et al.
Pubblicazione: (2026)
PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters.
di: Wang, Chaogang, et al.
Pubblicazione: (2024)
di: Wang, Chaogang, et al.
Pubblicazione: (2024)
Aeruginosin 525 (AER525) from Cyanobacterium Sp. (KUCC C2): A New Serine Proteases Inhibitor.
di: Overlingė, Donata, et al.
Pubblicazione: (2024)
di: Overlingė, Donata, et al.
Pubblicazione: (2024)
Hippo-YAP pathway regulates antimicrobial immune response in obscure puffer Takifugu obscurus.
di: Wang, Ruixia, et al.
Pubblicazione: (2025)
di: Wang, Ruixia, et al.
Pubblicazione: (2025)
Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress.
di: Ye, Haicheng, et al.
Pubblicazione: (2025)
di: Ye, Haicheng, et al.
Pubblicazione: (2025)
Computational insights into marine natural products as potential antidiabetic agents targeting the SIK2 protein kinase domain.
di: Heyram, K, et al.
Pubblicazione: (2024)
di: Heyram, K, et al.
Pubblicazione: (2024)
Design, Synthesis, and Evaluation of a Potent and Selective ROCK2 Inhibitor for Atopic Dermatitis Treatment.
di: Mao, Churu, et al.
Pubblicazione: (2026)
di: Mao, Churu, et al.
Pubblicazione: (2026)
Sun Exposure and Skin Cancer: A Narrative Review of Risk Factors, Prevention Behaviors, and Emerging Therapeutic Approaches
di: Silva, Luiz Felipe Rodrigues, et al.
Pubblicazione: (2026)
di: Silva, Luiz Felipe Rodrigues, et al.
Pubblicazione: (2026)
MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.
di: Huang, Yuhan, et al.
Pubblicazione: (2026)
di: Huang, Yuhan, et al.
Pubblicazione: (2026)
Change of the mTOR Pathway in Tissues of Overfed Geese
di: C Han
Pubblicazione: (2015)
di: C Han
Pubblicazione: (2015)
Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches.
di: Saif, Ahmed, et al.
Pubblicazione: (2025)
di: Saif, Ahmed, et al.
Pubblicazione: (2025)
Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
di: Mao, Churu, et al.
Pubblicazione: (2024)
di: Mao, Churu, et al.
Pubblicazione: (2024)
Regulation of the non-selective Na importer capacity of NRT1.2/NPF4.6/AIT1 by SOS2-mediated phosphorylation in Arabidopsis.
di: Liu, Xiaoxiao, et al.
Pubblicazione: (2025)
di: Liu, Xiaoxiao, et al.
Pubblicazione: (2025)
Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment.
di: Chen, Xiaohui, et al.
Pubblicazione: (2025)
di: Chen, Xiaohui, et al.
Pubblicazione: (2025)
Documenti analoghi
-
Computational Analysis of Azole Derivatives Targeting the PI3K/AKT/mTOR Pathway With In Vitro Cytotoxicity and Autophagy Evaluation.
di: Regurajan, Rathika, et al.
Pubblicazione: (2026) -
DHA affects ISKNV-induced autophagy flux via the AMPK/mTOR/ULK1 and BECN1/SQSTM1 axes, limiting viral replication in fish cells.
di: Chen, Kuang-Wen, et al.
Pubblicazione: (2026) -
Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.
di: Zhang, Xinyu, et al.
Pubblicazione: (2025) -
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.
di: Xie, Zhangdan, et al.
Pubblicazione: (2025) -
Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Extract Through Tor Signaling Modulation in .
di: Tahan Zadeh, Navid, et al.
Pubblicazione: (2025)