Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation.
Fuente:
PubMed
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Artículo científico |
| Sprache: | en |
| Veröffentlicht: |
Proceedings of the Japan Academy. Series B, Physical and biological sciences
2026
|
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1868266039378182145 |
|---|---|
| author | Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi |
| author_facet | Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi |
| collection | PubMed - marine biology |
| contents | Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation. Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi Depression remains a global mental health challenge, with current treatments often limited by therapeutic instability, side effects, and patient adherence. This study investigated Exocarpium Citri Grandis essential oil (ECG oil) as a natural antidepressant. Extraction was optimized using Plackett-Burman Design-Response Surface Methodology (PBD-RSM), achieving a 15.224% yield. GC-MS analysis identified D-limonene, α/β-pinene, and γ-terpinene as major active components. In vivo, both oral and nebulized ECG oil significantly alleviated depressive-like behaviors in a zebrafish larval model and chronic unpredictable mild stress (CUMS) mice (evidenced by tail suspension, open field, forced swim, and sucrose preference tests). Biochemically, ECG oil enhanced neurotransmitter activity and reduced monoamine oxidase A (MAOA) levels. Furthermore, network pharmacology coupled with molecular docking and experimental validation (qRT-PCR and Western blot) revealed that ECG oil exerts its efficacy by modulating key targets, including OXT, ESR1, PTGS2, and LEP. Conclusively, ECG oil represents a promising natural therapeutic for depression by regulating neurotransmitter and neuroinflammatory pathways. |
| format | Artículo científico |
| id | pubmed_42270402 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Proceedings of the Japan Academy. Series B, Physical and biological sciences |
| record_format | pubmed |
| spellingShingle | Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation. Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation. Li, Kang Zhong, Yijing Waqas, Muhammad Yin, Hongming Kong, Zhile Huang, Zunnan Qi, Yi Depression remains a global mental health challenge, with current treatments often limited by therapeutic instability, side effects, and patient adherence. This study investigated Exocarpium Citri Grandis essential oil (ECG oil) as a natural antidepressant. Extraction was optimized using Plackett-Burman Design-Response Surface Methodology (PBD-RSM), achieving a 15.224% yield. GC-MS analysis identified D-limonene, α/β-pinene, and γ-terpinene as major active components. In vivo, both oral and nebulized ECG oil significantly alleviated depressive-like behaviors in a zebrafish larval model and chronic unpredictable mild stress (CUMS) mice (evidenced by tail suspension, open field, forced swim, and sucrose preference tests). Biochemically, ECG oil enhanced neurotransmitter activity and reduced monoamine oxidase A (MAOA) levels. Furthermore, network pharmacology coupled with molecular docking and experimental validation (qRT-PCR and Western blot) revealed that ECG oil exerts its efficacy by modulating key targets, including OXT, ESR1, PTGS2, and LEP. Conclusively, ECG oil represents a promising natural therapeutic for depression by regulating neurotransmitter and neuroinflammatory pathways. |
| title | Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation. |
| url | https://pubmed.ncbi.nlm.nih.gov/42270402/ |