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| Hauptverfasser: | , , , , |
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| Format: | Artículo científico |
| Sprache: | en |
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Acta biochimica et biophysica Sinica
2026
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| Online-Zugang: | https://pubmed.ncbi.nlm.nih.gov/42272344/ |
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| _version_ | 1868266039375036418 |
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| author | Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan |
| author_facet | Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan |
| collection | PubMed - marine biology |
| contents | The intratumoral microbiota: from origin and identification to function and therapeutic perspective. Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan Tumor tissues, once considered sterile, actually host diverse microbial communities that play key roles in several physiological and pathological processes, closely related to tumorigenesis and progression. Studies have demonstrated that intratumoral microbiota potentially contributes to immune regulation and significantly influences cancer treatment outcomes. Here, we aim to provide an extensive review of the conceptual framework, potential origins, spatial heterogeneity, and analytical methodologies of intratumoral microbiota, explore their carcinogenic mechanisms and potential role in tumor prognosis. In addition, we discuss current therapeutic strategies that target intratumoral microbiota and highlight the research prospects and limitations in this field, although there are some inevitable challenges. |
| format | Artículo científico |
| id | pubmed_42272344 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Acta biochimica et biophysica Sinica |
| record_format | pubmed |
| spellingShingle | The intratumoral microbiota: from origin and identification to function and therapeutic perspective. Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan The intratumoral microbiota: from origin and identification to function and therapeutic perspective. Guo, Feiyue Zhuang, Wanru Huang, Jingyan Dong, Yuping Xie, Haiyan Tumor tissues, once considered sterile, actually host diverse microbial communities that play key roles in several physiological and pathological processes, closely related to tumorigenesis and progression. Studies have demonstrated that intratumoral microbiota potentially contributes to immune regulation and significantly influences cancer treatment outcomes. Here, we aim to provide an extensive review of the conceptual framework, potential origins, spatial heterogeneity, and analytical methodologies of intratumoral microbiota, explore their carcinogenic mechanisms and potential role in tumor prognosis. In addition, we discuss current therapeutic strategies that target intratumoral microbiota and highlight the research prospects and limitations in this field, although there are some inevitable challenges. |
| title | The intratumoral microbiota: from origin and identification to function and therapeutic perspective. |
| url | https://pubmed.ncbi.nlm.nih.gov/42272344/ |