Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
PNAS nexus
2026
|
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42273404/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- A transfer RNA inosine modification drives genome-wide synonymous recoding across human commensal bacterial families. Katanski, Christopher D Pathirage, Chathuri Chang, Jennifer C Veseli, Iva Smith, Tyler J Foo, Marcus Wu, Yuan Hou, Yichen Tran, Hoang Anh V Rudzka, Dominika Zhang, Wen Bayat Tork, Mohammad Amin Lolans, Karen Willis, Amy D Tang, Weixin Eren, A Murat Federle, Michael J Koutmou, Kristin S Pan, Tao Inosine modification on transfer RNA (tRNA) anticodon (I34) is universally conserved in three kingdoms of life and critical to tRNA decoding capabilities. We found that tRNA(IAG) in commensal human bacterial families in Lactobaccilalles is concurrent with genome-wide synonymous leucine codon reprogramming. Pathway analysis reveals significant synonymous Leu codon changes in proteins in multiple KEGG pathways on cellular metabolism, where many genome-wide dominant UUA in families without tRNA(IAG) is reprogrammed to CUU, CUC, and UUG in families with tRNA(IAG). We provide biochemical and phenotypic results to support mechanisms that enable synonymous Leu codon substitutions to confer greater translation equivalency and growth fitness, indicating that a tRNA inosine modification can propel the genome-wide evolution of synonymous leucine codons.