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| Main Authors: | , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Biology
2026
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| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42274508/ |
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| _version_ | 1868266037105917954 |
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| author | Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun |
| author_facet | Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun |
| collection | PubMed - marine biology |
| contents | GnRH Regulates Sex Differentiation in Through TGF-β/MAPK Signaling Pathways. Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun Sex determination and gonadal differentiation are essential for vertebrate development and reproduction. Fish, with both genetic and environmental sex-determining mechanisms, serve as ideal models for exploring environmental effects on gonadal development. The hypothalamic-pituitary-gonadal (HPG) axis is involved in sex differentiation, but its role as a key mediator in temperature-dependent sex differentiation remains unclear. is an economically important marine fish species along the northern coast of China. It exhibits obvious sexual growth dimorphism and typical temperature-dependent sex differentiation, making it an excellent model for investigating the mechanism of sex differentiation. In this study, individuals of at the sex differentiation stage were treated with a GnRH receptor antagonist and subjected to transcriptome sequencing analysis. The results revealed that GnRH may regulate sex differentiation through steroid biosynthesis, TGF-β and MAPK signaling pathways. We identified several key genes, including , , , , , and , which may affect gonadal differentiation by acting on core sex-determining genes and steroidogenesis. In conclusion, GnRH precisely mediates the process of sex differentiation by modulating the TGF-β signaling pathway, the MAPK signaling pathway, and local gonadal steroidogenic networks. |
| format | Artículo científico |
| id | pubmed_42274508 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Biology |
| record_format | pubmed |
| spellingShingle | GnRH Regulates Sex Differentiation in Through TGF-β/MAPK Signaling Pathways. Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun GnRH Regulates Sex Differentiation in Through TGF-β/MAPK Signaling Pathways. Huang, Jinwei Xu, Pingrui Xiao, Yongshuang Li, Jun Sex determination and gonadal differentiation are essential for vertebrate development and reproduction. Fish, with both genetic and environmental sex-determining mechanisms, serve as ideal models for exploring environmental effects on gonadal development. The hypothalamic-pituitary-gonadal (HPG) axis is involved in sex differentiation, but its role as a key mediator in temperature-dependent sex differentiation remains unclear. is an economically important marine fish species along the northern coast of China. It exhibits obvious sexual growth dimorphism and typical temperature-dependent sex differentiation, making it an excellent model for investigating the mechanism of sex differentiation. In this study, individuals of at the sex differentiation stage were treated with a GnRH receptor antagonist and subjected to transcriptome sequencing analysis. The results revealed that GnRH may regulate sex differentiation through steroid biosynthesis, TGF-β and MAPK signaling pathways. We identified several key genes, including , , , , , and , which may affect gonadal differentiation by acting on core sex-determining genes and steroidogenesis. In conclusion, GnRH precisely mediates the process of sex differentiation by modulating the TGF-β signaling pathway, the MAPK signaling pathway, and local gonadal steroidogenic networks. |
| title | GnRH Regulates Sex Differentiation in Through TGF-β/MAPK Signaling Pathways. |
| url | https://pubmed.ncbi.nlm.nih.gov/42274508/ |