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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
International journal of molecular sciences
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/42278320/ |
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| _version_ | 1868266037094383616 |
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| author | Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El |
| author_facet | Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El |
| collection | PubMed - marine biology |
| contents | Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth of and . Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El Microcystis Oxidative Stress Lichens Chlorella Volatile Organic Compounds Molecular Docking Simulation Microbial Sensitivity Tests Plant Extracts This study evaluates volatile extracts (HE1 and HE2) from the lichen as eco-friendly agents to control algal proliferation, specifically targeting the cyanobacterium and the green microalga . Both extracts exhibited potent anti-microalgal activity against the two species with a minimum inhibitory concentration (MIC) ranging from 375 to 750 µg/mL. Furthermore, both extracts reduced cell density by more than 98% after eight days of treatment. Chlorophyll and protein levels decreased significantly (>80%) in both species, indicating suppression of pigment synthesis. However, their physiological responses were distinct: underwent early acute oxidative stress and severe membrane damage, while exhibited delayed oxidative activation and a negative growth rate, suggesting non-lytic metabolic inhibition. An in silico study by molecular docking of the most abundant compounds identified in these volatile extracts, such as terpenoids (abietatriene, δ-cadinene) and a phenolic compound (atraric acid), showed that these compounds interact with vital cellular targets in and and likely contribute to the effects observed in these two species. Predictive toxicity by applying the ADMET framework confirmed the favorable bioavailability and low acute toxicity of these volatile compounds. Therefore, volatiles are promising, species-specific, and environmentally safe candidates for mitigating aquatic algal proliferation through targeted oxidative and metabolic interference. |
| format | Artículo científico |
| id | pubmed_42278320 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth of and . Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El Microcystis Oxidative Stress Lichens Chlorella Volatile Organic Compounds Molecular Docking Simulation Microbial Sensitivity Tests Plant Extracts Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth of and . Essadki, Yasser Darrag, El Mehdi Zerrifi, Soukaina El Amrani Haida, Mohamed Krimech, Aafaf Martins, Rosario Campos, Alexandre Vasconcelos, Vitor Bouaïcha, Noureddine Baçaoui, Abdelaziz Meddich, Abdelilah Oudra, Brahim Tazart, Zakaria Khalloufi, Fatima El Microcystis Oxidative Stress Lichens Chlorella Volatile Organic Compounds Molecular Docking Simulation Microbial Sensitivity Tests Plant Extracts This study evaluates volatile extracts (HE1 and HE2) from the lichen as eco-friendly agents to control algal proliferation, specifically targeting the cyanobacterium and the green microalga . Both extracts exhibited potent anti-microalgal activity against the two species with a minimum inhibitory concentration (MIC) ranging from 375 to 750 µg/mL. Furthermore, both extracts reduced cell density by more than 98% after eight days of treatment. Chlorophyll and protein levels decreased significantly (>80%) in both species, indicating suppression of pigment synthesis. However, their physiological responses were distinct: underwent early acute oxidative stress and severe membrane damage, while exhibited delayed oxidative activation and a negative growth rate, suggesting non-lytic metabolic inhibition. An in silico study by molecular docking of the most abundant compounds identified in these volatile extracts, such as terpenoids (abietatriene, δ-cadinene) and a phenolic compound (atraric acid), showed that these compounds interact with vital cellular targets in and and likely contribute to the effects observed in these two species. Predictive toxicity by applying the ADMET framework confirmed the favorable bioavailability and low acute toxicity of these volatile compounds. Therefore, volatiles are promising, species-specific, and environmentally safe candidates for mitigating aquatic algal proliferation through targeted oxidative and metabolic interference. |
| title | Lichen Extracts Containing Volatile Compounds Induce Oxidative Stress and Modulate the Growth of and . |
| topic | Microcystis Oxidative Stress Lichens Chlorella Volatile Organic Compounds Molecular Docking Simulation Microbial Sensitivity Tests Plant Extracts |
| url | https://pubmed.ncbi.nlm.nih.gov/42278320/ |