Black Sea-Derived Biomaterials for Wound-Healing Applications.
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| Natura: | Artículo científico |
| Lingua: | en |
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International journal of molecular sciences
2026
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| _version_ | 1868266037092286465 |
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| author | Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica |
| author_facet | Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica |
| collection | PubMed - marine biology |
| contents | Black Sea-Derived Biomaterials for Wound-Healing Applications. Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica Wound Healing Animals Biocompatible Materials Chitosan Collagen Humans Scyphozoa Chlorophyta Fibroblasts Polysaccharides Keratinocytes Antioxidants Wound healing is a complex, multi-stage process governed by tightly regulated molecular mechanisms. However, effective regenerative therapies remain with limitations. This study presents a novel marine-derived biocomposite, JPC-ALG-CT, designed to improve wound healing through synergistic bioactive mechanisms. The material incorporates collagen extracted from the jellyfish , chitosan derived from the crab , and polysaccharide-rich extracts from the green alga , all sourced from the Black Sea. The study is based on the biochemical analysis of these three marine-derived components, highlighting the collagen content of jellyfish, the polysaccharides present in algae, and the bioactive properties of chitosan. The biochemical and physico-chemical properties of each component were characterized, with particular emphasis on the structural features of jellyfish collagen and the functional bioactivity of chitosan and algal polysaccharides. The research findings are supported by the identification of the collagen type extracted from jellyfish, as well as by the characterization of chitosan and green algal extracts. The resulting composite demonstrated significant antioxidant and antimicrobial activities, indicating its potential to integrate key processes involved in wound repair, including inflammation control and microbial protection. In vitro studies using fibroblast and keratinocyte models showed that the JPC-CT-ALG biocomposite supported cell viability at lower tested concentrations and promoted scratch closure in cell monolayers, suggesting preliminary wound-relevant biological activity. These findings suggest that the combined marine-derived components interact to enchance wound healing at the cellular level. This work evidenced the potential of marine biomaterials as sources for next-generation regenerative therapies and supports further investigation into their molecular mechanisms and in vivo applications for improved wound care. |
| format | Artículo científico |
| id | pubmed_42278590 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | International journal of molecular sciences |
| record_format | pubmed |
| spellingShingle | Black Sea-Derived Biomaterials for Wound-Healing Applications. Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica Wound Healing Animals Biocompatible Materials Chitosan Collagen Humans Scyphozoa Chlorophyta Fibroblasts Polysaccharides Keratinocytes Antioxidants Black Sea-Derived Biomaterials for Wound-Healing Applications. Cadar, Emin Roncea, Florentina Nicoleta Roșca, Adrian Cosmin Peșterău, Ana-Maria Albu, Cristina-Crenguța Bubulac, Lucia Drăgan, Laura Ana-Maria Jurja, Sanda Bogdan-Andreescu, Claudia Florina Stoicescu, Iuliana Sirbu, Rodica Wound Healing Animals Biocompatible Materials Chitosan Collagen Humans Scyphozoa Chlorophyta Fibroblasts Polysaccharides Keratinocytes Antioxidants Wound healing is a complex, multi-stage process governed by tightly regulated molecular mechanisms. However, effective regenerative therapies remain with limitations. This study presents a novel marine-derived biocomposite, JPC-ALG-CT, designed to improve wound healing through synergistic bioactive mechanisms. The material incorporates collagen extracted from the jellyfish , chitosan derived from the crab , and polysaccharide-rich extracts from the green alga , all sourced from the Black Sea. The study is based on the biochemical analysis of these three marine-derived components, highlighting the collagen content of jellyfish, the polysaccharides present in algae, and the bioactive properties of chitosan. The biochemical and physico-chemical properties of each component were characterized, with particular emphasis on the structural features of jellyfish collagen and the functional bioactivity of chitosan and algal polysaccharides. The research findings are supported by the identification of the collagen type extracted from jellyfish, as well as by the characterization of chitosan and green algal extracts. The resulting composite demonstrated significant antioxidant and antimicrobial activities, indicating its potential to integrate key processes involved in wound repair, including inflammation control and microbial protection. In vitro studies using fibroblast and keratinocyte models showed that the JPC-CT-ALG biocomposite supported cell viability at lower tested concentrations and promoted scratch closure in cell monolayers, suggesting preliminary wound-relevant biological activity. These findings suggest that the combined marine-derived components interact to enchance wound healing at the cellular level. This work evidenced the potential of marine biomaterials as sources for next-generation regenerative therapies and supports further investigation into their molecular mechanisms and in vivo applications for improved wound care. |
| title | Black Sea-Derived Biomaterials for Wound-Healing Applications. |
| topic | Wound Healing Animals Biocompatible Materials Chitosan Collagen Humans Scyphozoa Chlorophyta Fibroblasts Polysaccharides Keratinocytes Antioxidants |
| url | https://pubmed.ncbi.nlm.nih.gov/42278590/ |