Suaeglaucin C: a new coumaronochromone isolated from .
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| Main Authors: | , , , , , |
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| Format: | Artículo científico |
| Language: | en |
| Published: |
Journal of Asian natural products research
2026
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| _version_ | 1868266037090189312 |
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| author | Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo |
| author_facet | Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo |
| collection | PubMed - marine biology |
| contents | Suaeglaucin C: a new coumaronochromone isolated from . Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo Animals Zebrafish Molecular Structure Humans Chenopodiaceae Chromones Verapamil Digoxin Drug Screening Assays, Antitumor HCT116 Cells A new coumaronochromone (), and 12 known compounds (-) were isolated from the ethyl acetate part of an aqueous EtOH extract of Compounds - and effectively ameliorated pericardial edema and venous congestion in zebrafish embryos induced by verapamil hydrochloride at 50 μM. Among these, exhibited superior efficacy in reducing pericardial edema compared to the positive control, Digoxin. In contrast, - displayed significant lethality in zebrafish embryos, with LC values of 9.41, 39.59, and 24.47 μM, respectively. Furthermore, these three compounds showed potential cytotoxic effects on HCT116 cells at 30 and 50 μM. |
| format | Artículo científico |
| id | pubmed_42283297 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Journal of Asian natural products research |
| record_format | pubmed |
| spellingShingle | Suaeglaucin C: a new coumaronochromone isolated from . Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo Animals Zebrafish Molecular Structure Humans Chenopodiaceae Chromones Verapamil Digoxin Drug Screening Assays, Antitumor HCT116 Cells Suaeglaucin C: a new coumaronochromone isolated from . Jia, Jia Ding, Xian-Rui Zang, Xiao-Han Fang, Ying-Jun Mao, Jin-Long Xu, Kuo Animals Zebrafish Molecular Structure Humans Chenopodiaceae Chromones Verapamil Digoxin Drug Screening Assays, Antitumor HCT116 Cells A new coumaronochromone (), and 12 known compounds (-) were isolated from the ethyl acetate part of an aqueous EtOH extract of Compounds - and effectively ameliorated pericardial edema and venous congestion in zebrafish embryos induced by verapamil hydrochloride at 50 μM. Among these, exhibited superior efficacy in reducing pericardial edema compared to the positive control, Digoxin. In contrast, - displayed significant lethality in zebrafish embryos, with LC values of 9.41, 39.59, and 24.47 μM, respectively. Furthermore, these three compounds showed potential cytotoxic effects on HCT116 cells at 30 and 50 μM. |
| title | Suaeglaucin C: a new coumaronochromone isolated from . |
| topic | Animals Zebrafish Molecular Structure Humans Chenopodiaceae Chromones Verapamil Digoxin Drug Screening Assays, Antitumor HCT116 Cells |
| url | https://pubmed.ncbi.nlm.nih.gov/42283297/ |