Bacteriophages hijack 2',3'-cNMPs to enhance transposase-mediated phage DNA integration in .
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Science advances
2026
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| _version_ | 1868266037087043585 |
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| author | Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue |
| author_facet | Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue |
| collection | PubMed - marine biology |
| contents | Bacteriophages hijack 2',3'-cNMPs to enhance transposase-mediated phage DNA integration in . Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue Acinetobacter baumannii Bacteriophages DNA, Viral Transposases Virus Integration Promoter Regions, Genetic Bacterial Proteins Nucleotide second messengers are widely used to mediate the physiology and antiphage immunity in bacteria. It was revealed that 2',3'-cAMP/2',3'-cGMP synthetase activity is required for immune response in plants. However, it remains unclear whether 2',3'-cNMPs are involved in the interactions between bacteria and phages. Here, we report that 2',3'-cNMPs, which are synthesized by RnaA and degraded by A1S_2339, A1S_0249, and A1S_2666, play critical roles in the modulation of the physiology of . 2',3'-cNMPs specifically bind to the receptor protein CRP in and thus affect the interaction between CRP and the promoters of target genes. Furthermore, our study reveals that bacteriophages elevate 2',3'-cNMPs to up-regulate the transcription of the transposases and Mu-like integrases required for bacteriophage DNA integration. Together, our results show that 2',3'-cNMPs are important intracellular signals that control biological functions of , and bacteriophages could hijack these signals to facilitate phage DNA integration. |
| format | Artículo científico |
| id | pubmed_42284395 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Science advances |
| record_format | pubmed |
| spellingShingle | Bacteriophages hijack 2',3'-cNMPs to enhance transposase-mediated phage DNA integration in . Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue Acinetobacter baumannii Bacteriophages DNA, Viral Transposases Virus Integration Promoter Regions, Genetic Bacterial Proteins Bacteriophages hijack 2',3'-cNMPs to enhance transposase-mediated phage DNA integration in . Cui, Binbin Ling, Xiwen Peng, Ganjin Guo, Quan Kong, Xiaohan Wang, Rixiang Ma, Yingfei Deng, Pujuan Cai, Hua Wang, Xiaoxue Deng, Yinyue Acinetobacter baumannii Bacteriophages DNA, Viral Transposases Virus Integration Promoter Regions, Genetic Bacterial Proteins Nucleotide second messengers are widely used to mediate the physiology and antiphage immunity in bacteria. It was revealed that 2',3'-cAMP/2',3'-cGMP synthetase activity is required for immune response in plants. However, it remains unclear whether 2',3'-cNMPs are involved in the interactions between bacteria and phages. Here, we report that 2',3'-cNMPs, which are synthesized by RnaA and degraded by A1S_2339, A1S_0249, and A1S_2666, play critical roles in the modulation of the physiology of . 2',3'-cNMPs specifically bind to the receptor protein CRP in and thus affect the interaction between CRP and the promoters of target genes. Furthermore, our study reveals that bacteriophages elevate 2',3'-cNMPs to up-regulate the transcription of the transposases and Mu-like integrases required for bacteriophage DNA integration. Together, our results show that 2',3'-cNMPs are important intracellular signals that control biological functions of , and bacteriophages could hijack these signals to facilitate phage DNA integration. |
| title | Bacteriophages hijack 2',3'-cNMPs to enhance transposase-mediated phage DNA integration in . |
| topic | Acinetobacter baumannii Bacteriophages DNA, Viral Transposases Virus Integration Promoter Regions, Genetic Bacterial Proteins |
| url | https://pubmed.ncbi.nlm.nih.gov/42284395/ |