Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.
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| Main Authors: | , , , , |
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| Format: | Artículo científico |
| Language: | en |
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Nature communications
2026
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| _version_ | 1868266037080752128 |
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| author | Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary |
| author_facet | Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary |
| collection | PubMed - marine biology |
| contents | Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction. Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary Oogenesis requires complex interactions between germline and somatic cell types in the ovary. How did these cell types and their signaling interactions evolve? Here we use the sea star Patiria miniata as a non-chordate deuterostome representative to define the ovarian cell type toolkit in echinoderms. Sea stars continuously produce millions of new oocytes throughout their lifespan, making them a practical system to understand the mechanisms that drive oogenesis from a biomedical and evolutionary perspective. We performed scRNA-seq combined with high-resolution 3D imaging to reveal the ovarian cell types and their spatial organization. Our data support the presence of putative oogonial stem cells, granulosa-like, and theca-like cells, which display similarities with their mammalian counterparts. We also describe possible signaling interactions between somatic and germ line cells. Lastly, our data may suggest an intrinsic ovarian neuroendocrine system which could potentially regulate oogenesis. |
| format | Artículo científico |
| id | pubmed_42288494 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Nature communications |
| record_format | pubmed |
| spellingShingle | Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction. Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction. Paganos, Periklis Naigles, Beverly Wolff, Carsten Voronov, Danila Swartz, S Zachary Oogenesis requires complex interactions between germline and somatic cell types in the ovary. How did these cell types and their signaling interactions evolve? Here we use the sea star Patiria miniata as a non-chordate deuterostome representative to define the ovarian cell type toolkit in echinoderms. Sea stars continuously produce millions of new oocytes throughout their lifespan, making them a practical system to understand the mechanisms that drive oogenesis from a biomedical and evolutionary perspective. We performed scRNA-seq combined with high-resolution 3D imaging to reveal the ovarian cell types and their spatial organization. Our data support the presence of putative oogonial stem cells, granulosa-like, and theca-like cells, which display similarities with their mammalian counterparts. We also describe possible signaling interactions between somatic and germ line cells. Lastly, our data may suggest an intrinsic ovarian neuroendocrine system which could potentially regulate oogenesis. |
| title | Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction. |
| url | https://pubmed.ncbi.nlm.nih.gov/42288494/ |