Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish () Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA.
Fuente:
PubMed
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Aquaculture nutrition
2026
|
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1868266037072363520 |
|---|---|
| author | Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner |
| author_facet | Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner |
| collection | PubMed - marine biology |
| contents | Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish () Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA. Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner Raw materials rich in EPA (C20:5n-3) and DHA (C22:6n-3) such as marine fish oils and meals are becoming increasingly scarce and valuable throughout the aquafeed industry, while human dietary intake of EPA and DHA is deficient in many parts of the world. Therefore, EPA and DHA sources have to be used judiciously and strategically in diets for especially freshwater fish, which, compared to their marine counterparts, tend to have a superior ability to biosynthesize these functionally important fatty acids (FAs) from their C precursors. Hence, this study tested the effect of a minimal dietary EPA + DHA level on growth performance, fillet and liver FA profile development, gene expression dynamics (, , and ), and nutrient excretion of African catfish () by replacing salmon oil with rapeseed oil in a marine-ingredient-free basal diet formulated with low EPA + DHA circular animal protein sources. Even though growth performance attained with a commercial African catfish diet utilizing the same salmon oil was not achieved with the two experimental diets, low EPA + DHA levels in the rapeseed oil experimental diet did not negatively affect growth. Expression of hepatic , , and was significantly elevated in the rapeseed oil-fed fish, while particularly EPA and DHA in the fillet, and EPA in the liver were consistently and significantly lower compared to the salmon oil-based diets. Concomitant examination of gene expression and FA profile development indicates the notable capacity of African catfish to de novo synthesize EPA and DHA from ALA (C18:3n-3), which suggests the potential of low EPA + DHA diets for this species. From a human nutritional point of view, however, this biosynthetic capacity was insufficient to compensate for the effect of the low EPA + DHA rapeseed oil diet on fillet FA profile quality, with EPA + DHA content and n-6:n-3 FA ratio being significantly negatively affected. Irrespective of oil source, the phosphorus-rich experimental diets resulted in a significantly improved ratio of excreted dissolved nitrogen to phosphorus compared to the industrial control from a plant nutrition perspective, confirming prior results on the ability to improve diets for use in aquaponics. |
| format | Artículo científico |
| id | pubmed_42292292 |
| institution | PubMed |
| language | en |
| publishDate | 2026 |
| publisher | Aquaculture nutrition |
| record_format | pubmed |
| spellingShingle | Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish () Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA. Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish () Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA. Shaw, Christopher Knopf, Klaus Wuertz, Sven Roy, Koushik Gebauer, Radek Goldhammer, Tobias Schöning, Viola Kleiner, Wibke Sens, Marvin Ulrichs, Christian Kloas, Werner Raw materials rich in EPA (C20:5n-3) and DHA (C22:6n-3) such as marine fish oils and meals are becoming increasingly scarce and valuable throughout the aquafeed industry, while human dietary intake of EPA and DHA is deficient in many parts of the world. Therefore, EPA and DHA sources have to be used judiciously and strategically in diets for especially freshwater fish, which, compared to their marine counterparts, tend to have a superior ability to biosynthesize these functionally important fatty acids (FAs) from their C precursors. Hence, this study tested the effect of a minimal dietary EPA + DHA level on growth performance, fillet and liver FA profile development, gene expression dynamics (, , and ), and nutrient excretion of African catfish () by replacing salmon oil with rapeseed oil in a marine-ingredient-free basal diet formulated with low EPA + DHA circular animal protein sources. Even though growth performance attained with a commercial African catfish diet utilizing the same salmon oil was not achieved with the two experimental diets, low EPA + DHA levels in the rapeseed oil experimental diet did not negatively affect growth. Expression of hepatic , , and was significantly elevated in the rapeseed oil-fed fish, while particularly EPA and DHA in the fillet, and EPA in the liver were consistently and significantly lower compared to the salmon oil-based diets. Concomitant examination of gene expression and FA profile development indicates the notable capacity of African catfish to de novo synthesize EPA and DHA from ALA (C18:3n-3), which suggests the potential of low EPA + DHA diets for this species. From a human nutritional point of view, however, this biosynthetic capacity was insufficient to compensate for the effect of the low EPA + DHA rapeseed oil diet on fillet FA profile quality, with EPA + DHA content and n-6:n-3 FA ratio being significantly negatively affected. Irrespective of oil source, the phosphorus-rich experimental diets resulted in a significantly improved ratio of excreted dissolved nitrogen to phosphorus compared to the industrial control from a plant nutrition perspective, confirming prior results on the ability to improve diets for use in aquaponics. |
| title | Compensatory Fatty Acid Metabolism and Hepatic Gene Expression in African Catfish () Fed Marine-Ingredient-Free Circular Diets Low in EPA and DHA. |
| url | https://pubmed.ncbi.nlm.nih.gov/42292292/ |