Serology for human papillomavirus
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| Format: | Artículo científico |
| Sprache: | en |
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Instituto Nacional de Salud Pública
2003
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| _version_ | 1876472300150194176 |
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| author | Pierre Coursaget |
| author_facet | Pierre Coursaget |
| contents | Serology for human papillomavirus Pierre Coursaget Salud VLP HPV serology cervical cancer Difficulties with serology for papillomavirus are associatedwith the large number of human papillomavirus, crossreactionsbetween papillomavirus, and to the diversity oflesions and target sites for infection. In addition, theexpression of the papillomavirus in the superficial layers ofthe epithelium gives rise to the weak presentation toimmunocompetent cells of viral antigens, which in turn givesrise to a weak serological response. Distinct efforts havebeen made in previous decades to develop more specificand sensitive serological assays. These former studies usefusion proteins and synthetic peptides, although they remainon the whole uninteresting, due to their lack of sensitivityand specificity. Only in the last few years, and principallydue to the advent of various virus-like particles (VLP), havemore sensitive and specific assays become available. Thispaper is available too at: http://www.insp.mx/salud/index.html 2003 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10609710 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.45 |
| format | Artículo científico |
| id | redalyc_10609710 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | Serology for human papillomavirus Pierre Coursaget Salud VLP HPV serology cervical cancer Serology for human papillomavirus Pierre Coursaget Salud VLP HPV serology cervical cancer Difficulties with serology for papillomavirus are associatedwith the large number of human papillomavirus, crossreactionsbetween papillomavirus, and to the diversity oflesions and target sites for infection. In addition, theexpression of the papillomavirus in the superficial layers ofthe epithelium gives rise to the weak presentation toimmunocompetent cells of viral antigens, which in turn givesrise to a weak serological response. Distinct efforts havebeen made in previous decades to develop more specificand sensitive serological assays. These former studies usefusion proteins and synthetic peptides, although they remainon the whole uninteresting, due to their lack of sensitivityand specificity. Only in the last few years, and principallydue to the advent of various virus-like particles (VLP), havemore sensitive and specific assays become available. Thispaper is available too at: http://www.insp.mx/salud/index.html 2003 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10609710 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.45 |
| title | Serology for human papillomavirus |
| topic | Salud VLP HPV serology cervical cancer |
| url | https://www.redalyc.org/articulo.oa?id=10609710 |