Maternal MTHFR polymorphisms and risk of spontaneous abortion
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| Format: | Artículo científico |
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Instituto Nacional de Salud Pública
2009
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| author | María del Rosario Rodríguez-Guillén |
| author_facet | María del Rosario Rodríguez-Guillén |
| contents | Maternal MTHFR polymorphisms and risk of spontaneous abortion María del Rosario Rodríguez-Guillén Luisa Torres-Sánchez Jia Chen Marcia Galván-Portillo Julia Blanco-Muñoz Miriam Aracely Anaya Irma Silva-Zolezzi María A. Hernández-Valero Lizbeth López-Carrillo Salud MTHFR Mexico spontaneous abortion 677 C>T and 1298 A>C polymorphisms Objective. To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). Material and Methods. We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. Results. Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% CI: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% CI: 1.1, 26.6). Conclusions. Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins. 2009 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10612548005 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.1 Vol.51 |
| format | Artículo científico |
| id | redalyc_10612548005 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | Maternal MTHFR polymorphisms and risk of spontaneous abortion María del Rosario Rodríguez-Guillén Salud MTHFR Mexico spontaneous abortion 677 C>T and 1298 A>C polymorphisms Maternal MTHFR polymorphisms and risk of spontaneous abortion María del Rosario Rodríguez-Guillén Luisa Torres-Sánchez Jia Chen Marcia Galván-Portillo Julia Blanco-Muñoz Miriam Aracely Anaya Irma Silva-Zolezzi María A. Hernández-Valero Lizbeth López-Carrillo Salud MTHFR Mexico spontaneous abortion 677 C>T and 1298 A>C polymorphisms Objective. To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). Material and Methods. We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. Results. Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% CI: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% CI: 1.1, 26.6). Conclusions. Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins. 2009 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10612548005 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.1 Vol.51 |
| title | Maternal MTHFR polymorphisms and risk of spontaneous abortion |
| topic | Salud MTHFR Mexico spontaneous abortion 677 C>T and 1298 A>C polymorphisms |
| url | https://www.redalyc.org/articulo.oa?id=10612548005 |