Prevención de la isoinmunización materna al RhD, con g-globulina anti-D
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| Format: | Artículo científico |
| Langue: | en |
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Instituto Nacional de Salud Pública
2001
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| _version_ | 1876457685967175680 |
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| author | Héctor Alfredo Baptista González |
| author_facet | Héctor Alfredo Baptista González |
| contents | Prevención de la isoinmunización materna al RhD, con g-globulina anti-D Héctor Alfredo Baptista González Fany Rosenfeld Mann Teresita Leiss Márquez Salud Mexico prevention & control Key words: Rh isoimmunization Objective. To report our experience in preventing RhDmaternal isoimmunization by using anti-D gamma globulinamong Rh-negative women. Material and methods. Between1982 and 1995, immunologic and hematologic datawere collected from all Rh-negative women seen at Mexico?sNational Perinatology Institute. Women at risk of Rhisoimmunization were given a prophylactic dose of 150 mgof anti-D gamma globulin. Results. A total of 4 857 Rhnegativewomen were seen during the study period (4.85%of the total population of women seen at the Institute),629 (13.0%) of whom developed RhD isoimmunization;542 (86.2%) of these women were already isoimmunizedwhen first seen at our Institute. Twenty-two women (3.5%)developed isoimmunization even after receiving a properdose of anti-D gamma globulin. Prophylaxis was given to2 605 women (53.6%); 2 039 received a single dose, and475 two doses. Prophylaxis failed in 22 cases; four werewomen with multiple pregnancy and 18 developed obstetricpathologic conditions. Conclusions. The use of anti-Dgamma globulin resulted in a reduction of maternal Rhisoimmunization to less than one case per 1 000 women.Failures to prevent isoimmunization were associated to additionalobstetric conditions and to lack of adherence toprevention guidelines. The English version of this paper isavailable at: http://www.insp.mx/salud/index.html 2001 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10643109 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.1 Vol.43 |
| format | Artículo científico |
| id | redalyc_10643109 |
| institution | Redalyc |
| language | en |
| publishDate | 2001 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | Prevención de la isoinmunización materna al RhD, con g-globulina anti-D Héctor Alfredo Baptista González Salud Mexico prevention & control Key words: Rh isoimmunization Prevención de la isoinmunización materna al RhD, con g-globulina anti-D Héctor Alfredo Baptista González Fany Rosenfeld Mann Teresita Leiss Márquez Salud Mexico prevention & control Key words: Rh isoimmunization Objective. To report our experience in preventing RhDmaternal isoimmunization by using anti-D gamma globulinamong Rh-negative women. Material and methods. Between1982 and 1995, immunologic and hematologic datawere collected from all Rh-negative women seen at Mexico?sNational Perinatology Institute. Women at risk of Rhisoimmunization were given a prophylactic dose of 150 mgof anti-D gamma globulin. Results. A total of 4 857 Rhnegativewomen were seen during the study period (4.85%of the total population of women seen at the Institute),629 (13.0%) of whom developed RhD isoimmunization;542 (86.2%) of these women were already isoimmunizedwhen first seen at our Institute. Twenty-two women (3.5%)developed isoimmunization even after receiving a properdose of anti-D gamma globulin. Prophylaxis was given to2 605 women (53.6%); 2 039 received a single dose, and475 two doses. Prophylaxis failed in 22 cases; four werewomen with multiple pregnancy and 18 developed obstetricpathologic conditions. Conclusions. The use of anti-Dgamma globulin resulted in a reduction of maternal Rhisoimmunization to less than one case per 1 000 women.Failures to prevent isoimmunization were associated to additionalobstetric conditions and to lack of adherence toprevention guidelines. The English version of this paper isavailable at: http://www.insp.mx/salud/index.html 2001 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10643109 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.1 Vol.43 |
| title | Prevención de la isoinmunización materna al RhD, con g-globulina anti-D |
| topic | Salud Mexico prevention & control Key words: Rh isoimmunization |
| url | https://www.redalyc.org/articulo.oa?id=10643109 |