Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention
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| Format: | Artículo científico |
| Langue: | en |
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Instituto Nacional de Salud Pública
2001
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| _version_ | 1876473285058756608 |
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| author | Germán R. Aguilar |
| author_facet | Germán R. Aguilar |
| contents | Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention Germán R. Aguilar Guadalupe Ayala Geny Fierros Salud Health Biology Vaccination Gastric cancer Helicobacter pylori Helicobacter pylori has aquired great importance during the last two decades, after being recognized as an important pathogen that infects a great proportion of the human population. This microorganism is recognized as the main causal agent of chronic gastritis and duodenal ulcers, and it is asociated with the subsequent development of gastric carcinoma. The pathogenic mechanisms of H. pylori and their relation to gastric aliments have not been clearly defined. However, at present it is well established that urease, vacuolating cytotoxin VacA, and the pathogenicity island (cag PAI) gene products, are the main factors of virulence of this organism. Thus, individuals infected with strains that express these virulence factors probably develop a severe local inflammation that may induce the development of peptic ulcer and gastric cancer. The way the infection spreads throughout the world suggests the possibility that there are multiple pathways of transmission. The objective of this review is to present the most relevant findings of the biology of H. pylori and its interaction with the human host. 2001 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10643312 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.43 |
| format | Artículo científico |
| id | redalyc_10643312 |
| institution | Redalyc |
| language | en |
| publishDate | 2001 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention Germán R. Aguilar Salud Health Biology Vaccination Gastric cancer Helicobacter pylori Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention Germán R. Aguilar Guadalupe Ayala Geny Fierros Salud Health Biology Vaccination Gastric cancer Helicobacter pylori Helicobacter pylori has aquired great importance during the last two decades, after being recognized as an important pathogen that infects a great proportion of the human population. This microorganism is recognized as the main causal agent of chronic gastritis and duodenal ulcers, and it is asociated with the subsequent development of gastric carcinoma. The pathogenic mechanisms of H. pylori and their relation to gastric aliments have not been clearly defined. However, at present it is well established that urease, vacuolating cytotoxin VacA, and the pathogenicity island (cag PAI) gene products, are the main factors of virulence of this organism. Thus, individuals infected with strains that express these virulence factors probably develop a severe local inflammation that may induce the development of peptic ulcer and gastric cancer. The way the infection spreads throughout the world suggests the possibility that there are multiple pathways of transmission. The objective of this review is to present the most relevant findings of the biology of H. pylori and its interaction with the human host. 2001 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10643312 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.43 |
| title | Helicobacter pylori: Recent advances in the study of its pathogenicity and prevention |
| topic | Salud Health Biology Vaccination Gastric cancer Helicobacter pylori |
| url | https://www.redalyc.org/articulo.oa?id=10643312 |