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| Format: | Artículo científico |
| Language: | en |
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Instituto Nacional de Salud Pública
2002
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| Online Access: | https://www.redalyc.org/articulo.oa?id=10644304 |
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Table of Contents:
- Factores de riesgo relacionados con lupus eritematoso sistémico en población mexicana Jorge Escobedo Abraham Zonana Leoncio Miguel Rodríguez Francisco Javier Jiménez Adolfo Camargo Antonio Fraga Salud Mexico risk factors Key words: lupus erythematosus systemic Objective. To assess risk factors associated with systemiclupus erythematosus (SLE) in the Mexican population. Materialand Methods. A case-control study was conductedon June 1996, at the Reumathology Clinic of Hospital deEspecialidades del Centro Médico Nacional Siglo XXI (HECMN), Instituto Mexicano del Seguro Social, in Mexico City.Cases were one hundred thirty subjects with four or moreSLE criteria and disease evolution of ± 5 years. Controlswere hospitalized patients with acute diseases but withoutautoimmune diseases. Cases and controls were matched1:1 by age and gender; both groups were evaluated by directinterview through a structured questionnaire. The followingrisk factors were assessed: genetic family history ofSLE and connective tissue disease; socioedemographic (ethnicity,geographic distribution, education, monthly income);hormonal (use of oral contraceptives, replacement therapyand gynecoobstetric background); environmental (use of hairproducts, living with dogs, bacterial/viral infections, and allergies).Statistical analysis consisted of odd ratios (OR) with95% confidence intervals (CI ) and multivariate analysis usinglogistic regression. Results. The multivariate modelshowed association with family history of SLE (OR 4.2, CI95% 1.17-15.2), family history of connective tissue disorder(OR 2.6, CI 95% 1.15-4.5), use of oral contraceptives formore than one year (OR 2.1, CI 95% 1.13-4.3), repetitivepharyngitis (OR 2.1, CI 95% 1.18-3.6), and use of medications(OR 5.0 IC 95% 1.62 - 21.6). No association was foundwith socieconomic status, hair dye products, asthma, or allergies.Conclusions. Genetic factors, such as family historyof SLE and connective tissue disease in first-degreerelatives, persist as important factors in the development ofSLE. Other factors, such as use of some drugs, oral contraceptives,and repetitive pharyngitis, may also favor the onsetof disease in genetically susceptible hosts. The Englishversion of this paper is available at: http://www.insp.mx/salud/index.html 2002 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10644304 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.3 Vol.44