Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico
Fuente:
Redalyc
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Instituto Nacional de Salud Pública
2003
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1876489346179137536 |
|---|---|
| author | Renán A Góngora |
| author_facet | Renán A Góngora |
| contents | Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico Renán A Góngora Carlos J Castro Dora M Lara Julio Garrido Víctor Lara Pedro González Salud Mexico liver cirrhosis hepatitis C virus hepatitis B virus carcinoma hepatocellular Objective. To report the prevalence of antibodies againstthe hepatitis C virus (anti-HCV) in a group of patients withhepatic cirrhosis (HC). Material and Methods. A prospectivetransversal and descriptive study was carried outfrom March 1998 to May 1999. Study subjects were 153patients; 117 (76%) male and 36 (24%) female, diagnosedwith HC. They were attended at the General Hospital AgustínO Horan and at Regional Research Center DoctorHideyo Noguchi, in Merida, Yucatan, Mexico. A clinical-epidemiologicquestionnaire completed by interview was usedfor data collection. Anti-HCV were detected using a 2ndgeneration enzyme-linked immunosorbent assay (ELISA-2).To confirm diagnosis, a second generation recombining immunoblotassay (RIBA-2) was used. Hepatitis B surface antigen(HbsAg) and antibodies against the hepatitis B coreantigen (anti-HBc) were determined using ELISA. The presenceof anti-HCV was related to the epidemiologic variablesof study subjects. The prevalence of anti-HCV wasobtained and the frequency of the characteristics obtainedby interview were compared among the positive and negativepatients through the c2 test and the Fishers exacttest, as needed. Results. Among patients with HC (35/117(30%) male and 14/36 (39%) female), 32 % were positive toanti-HCV. Alcoholism was present in all seroreactive malesand absent in all positive females (p< 0.001). Data obtainedthrough an interview were not associated with seropositivity. Anti-HBc was found in 16% of patients positive to anti-HCV and in 12% of seronegatives (p=0.69). Conclusions.The prevalence found was greater than previous reports inthe general population in the Yucatan Peninsula (1.3%). Thehigh prevalence of anti-HCV in these patients suggests thatHC is more frequently associated with HCV in Yucatan,Mexico than hepatitis B. Alcoholism probably acts as a cofactorfor the development of HC in males. 2003 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10645503 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.5 Vol.45 |
| format | Artículo científico |
| id | redalyc_10645503 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Instituto Nacional de Salud Pública |
| spellingShingle | Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico Renán A Góngora Salud Mexico liver cirrhosis hepatitis C virus hepatitis B virus carcinoma hepatocellular Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico Renán A Góngora Carlos J Castro Dora M Lara Julio Garrido Víctor Lara Pedro González Salud Mexico liver cirrhosis hepatitis C virus hepatitis B virus carcinoma hepatocellular Objective. To report the prevalence of antibodies againstthe hepatitis C virus (anti-HCV) in a group of patients withhepatic cirrhosis (HC). Material and Methods. A prospectivetransversal and descriptive study was carried outfrom March 1998 to May 1999. Study subjects were 153patients; 117 (76%) male and 36 (24%) female, diagnosedwith HC. They were attended at the General Hospital AgustínO Horan and at Regional Research Center DoctorHideyo Noguchi, in Merida, Yucatan, Mexico. A clinical-epidemiologicquestionnaire completed by interview was usedfor data collection. Anti-HCV were detected using a 2ndgeneration enzyme-linked immunosorbent assay (ELISA-2).To confirm diagnosis, a second generation recombining immunoblotassay (RIBA-2) was used. Hepatitis B surface antigen(HbsAg) and antibodies against the hepatitis B coreantigen (anti-HBc) were determined using ELISA. The presenceof anti-HCV was related to the epidemiologic variablesof study subjects. The prevalence of anti-HCV wasobtained and the frequency of the characteristics obtainedby interview were compared among the positive and negativepatients through the c2 test and the Fishers exacttest, as needed. Results. Among patients with HC (35/117(30%) male and 14/36 (39%) female), 32 % were positive toanti-HCV. Alcoholism was present in all seroreactive malesand absent in all positive females (p< 0.001). Data obtainedthrough an interview were not associated with seropositivity. Anti-HBc was found in 16% of patients positive to anti-HCV and in 12% of seronegatives (p=0.69). Conclusions.The prevalence found was greater than previous reports inthe general population in the Yucatan Peninsula (1.3%). Thehigh prevalence of anti-HCV in these patients suggests thatHC is more frequently associated with HCV in Yucatan,Mexico than hepatitis B. Alcoholism probably acts as a cofactorfor the development of HC in males. 2003 artículo científico 0036-3634 https://www.redalyc.org/articulo.oa?id=10645503 en http://www.redalyc.org/revista.oa?id=106 Salud Pública de México application/pdf Instituto Nacional de Salud Pública Salud Pública de México (México) Num.5 Vol.45 |
| title | Frequency of antibodies against the hepatitis C virus in patients with hepatic cirrhosis in Yucatan, Mexico |
| topic | Salud Mexico liver cirrhosis hepatitis C virus hepatitis B virus carcinoma hepatocellular |
| url | https://www.redalyc.org/articulo.oa?id=10645503 |